脾脏提取物和氢化可的松诱导同种异体移植耐受的抑制细胞机制的证据。
Evidence of suppresssor cell-mechanism of allograft tolerance induced by spleen extract and hydrocortisone.
作者信息
Rieger M, Günther J, Kristofová H, Hilgert I
出版信息
Folia Biol (Praha). 1978;24(3):145-61.
The mechanism of allograft tolerance in mice induced by cell-free spleen extract in combination with hydrocortisone was investigated. HC potentiated tolerance induction when given after the spleen extract. When HC was given before, or during the first 2 weeks of antigenic treatment, it counteracted rather than potentiated the tolerance-inducing effect. Spleen or lymph node cells transferred from tolerant donors to untreated or sublethally irradiated syngeneic recipients suppressed the recipients' response to the particular alloantigens. The suppressive activity of lymphoid cells from tolerant donors was abolished when before their transfer the subpopulation of T cells was eliminated by means of anti Thy-1.2 serum and complement. This finding suggests that suppressor T cells may be involved in tolerance induced by spleen extract and hydrocortisone.
研究了无细胞脾提取物与氢化可的松联合诱导小鼠同种异体移植耐受的机制。在给予脾提取物后给予氢化可的松可增强耐受诱导。当在抗原处理的前2周或期间给予氢化可的松时，它起抵消作用而非增强耐受诱导作用。从耐受供体转移至未处理或经亚致死剂量照射的同基因受体的脾或淋巴结细胞抑制了受体对特定同种异体抗原的反应。当通过抗Thy-1.2血清和补体在转移前消除T细胞亚群时，来自耐受供体的淋巴细胞的抑制活性被消除。这一发现表明，抑制性T细胞可能参与了脾提取物和氢化可的松诱导的耐受。
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