Zhuang Chunlan, Liu Xiaohui, Chen Qi, Sun Yuxin, Su Yingying, Huang Shoujie, Wu Ting, Xia Ningshao
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health, Xiamen University, Xiamen, China.
School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Front Microbiol. 2022 Feb 22;13:828806. doi: 10.3389/fmicb.2022.828806. eCollection 2022.
The coronavirus disease 2019 (COVID-19) vaccines have very successfully decreased the disease risk as we know; some key information remains unknown due to the short development history and the lack of long-term follow-up studies in vaccinated populations. One of the unanswered issues is the protection duration conferred after COVID-19 vaccination, which appears to play a pivotal role in the future impact of pathogens and is critical to inform the public health response and policy decisions. Here, we review current information on the long-term effectiveness of different COVID-19 vaccines, persistence of immunogenicity, and gaps in knowledge. Meanwhile, we also discuss the influencing factors and future study prospects on this topic.
我们知道，2019冠状病毒病（COVID-19）疫苗已非常成功地降低了疾病风险；但由于研发历史较短且缺乏对接种人群的长期随访研究，一些关键信息仍不明确。未得到解答的问题之一是COVID-19疫苗接种后的保护持续时间，这似乎在病原体未来的影响中起着关键作用，对于为公共卫生应对措施和政策决策提供信息至关重要。在此，我们综述了关于不同COVID-19疫苗长期有效性、免疫原性持久性以及知识空白的现有信息。同时，我们也讨论了该主题的影响因素和未来研究前景。
