Department of Bioengineering, College of Engineering, Hanayang University, Seoul, South Korea.
Institute of Nano Science and Technology (INST), Hanayang University, Seoul, South Korea.
Front Immunol. 2022 Feb 22;13:826876. doi: 10.3389/fimmu.2022.826876. eCollection 2022.
Immunotherapy holds enormous promise to create a new outlook of cancer therapy by eliminating tumors activation of the immune system. In immunotherapy, polymeric systems play a significant role in improving antitumor efficacy and safety profile. Polymeric systems possess many favorable properties, including magnificent biocompatibility and biodegradability, structural and component diversity, easy and controllable fabrication, and high loading capacity for immune-related substances. These properties allow polymeric systems to perform multiple functions in immunotherapy, such as immune stimulants, modifying and activating T cells, delivery system for immune cargos, or as an artificial antigen-presenting cell. Among diverse immunotherapies, immune checkpoint inhibitors, chimeric antigen receptor (CAR) T cell, and oncolytic virus recently have been dramatically investigated for their remarkable success in clinical trials. In this report, we review the monotherapy status of immune checkpoint inhibitors, CAR-T cell, and oncolytic virus, and their current combination strategies with diverse polymeric systems.
免疫疗法通过激活免疫系统来消除肿瘤，为癌症治疗带来了新的前景。在免疫疗法中，聚合物系统在提高抗肿瘤疗效和安全性方面发挥着重要作用。聚合物系统具有许多优良的特性，包括极好的生物相容性和生物降解性、结构和成分的多样性、易于制造和可控性以及对免疫相关物质的高负载能力。这些特性使得聚合物系统能够在免疫疗法中发挥多种功能，如免疫刺激剂、修饰和激活 T 细胞、免疫载体的递送系统，或作为人工抗原呈递细胞。在各种免疫疗法中，免疫检查点抑制剂、嵌合抗原受体 (CAR) T 细胞和溶瘤病毒最近因其在临床试验中的显著成功而受到了广泛的研究。在本报告中，我们综述了免疫检查点抑制剂、CAR-T 细胞和溶瘤病毒的单药治疗现状及其与各种聚合物系统的联合策略。
