喉软化症婴儿的周期性交替模式特征
Characterization of cyclic alternating pattern in infants with laryngomalacia.
作者信息
Cáceres Laura Mendoza, Vargas Ángel Daniel Santana, Rosas Gabriela Millán, Pérez Eduardo Barragán, Poblano Adrián, Miranda Rafael Santana
机构信息
Universidad Nacional Autónoma de México, Facultad de Medicina, Sleep disorders Clinic - Mexico City - Mexico.
General Hospital of Mexico, Department of Research - Mexico City - Mexico.
出版信息
Sleep Sci. 2022 Jan-Mar;15(Spec 1):229-233. doi: 10.5935/1984-0063.20210017.
OBJECTIVE
Cyclic alternanting pattern (CAP) has been considered a marker of sleep instability in children. The aim of this study was to evaluate the CAP in infants with laryngomalacia.
MATERIAL AND METHODS
CAP were quantified in 15 infants with laryngomalacia (mean age 167.2±97.21 days) and 10 controls (mean age of 158.5±116.2 days) using polysomnography.
RESULTS
The distribution of the A2 subtypes across NREM stages in infants with laryngomalacia showed a decrease, as well as in the mean duration of CAP sequences. The A3 CAP and arousals increased in infants with laryngomalacia. Our data showed a stronger correlation between the mean duration of A1 CAP and the age in healthy controls than in infants with laryngomalacia. In accordance to previous reports infants with laryngomalacia exhibited an increase in total awake time, apnea-hypopnea index, and a decrease in N3 stage compared to controls.
DISCUSSION
Our findings add to a growing body of literature of CAP as an indicator of brain maturation.
目的
周期性交替模式（CAP）被认为是儿童睡眠不稳定性的一个指标。本研究的目的是评估喉软化症婴儿的CAP情况。
材料与方法
使用多导睡眠图对15例喉软化症婴儿（平均年龄167.2±97.21天）和10例对照婴儿（平均年龄158.5±116.2天）的CAP进行量化。
结果
喉软化症婴儿中A2亚型在非快速眼动睡眠阶段的分布以及CAP序列的平均持续时间均有所减少。喉软化症婴儿的A3 CAP和觉醒次数增加。我们的数据显示，与喉软化症婴儿相比，健康对照婴儿中A1 CAP的平均持续时间与年龄之间的相关性更强。与之前的报告一致，与对照相比，喉软化症婴儿的总清醒时间、呼吸暂停低通气指数增加，N3期减少。
讨论
我们的研究结果进一步丰富了将CAP作为脑成熟指标的文献。
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