多潘立酮，一种新型多巴胺拮抗剂。
Domperidone, a new dopamine antagonist.
作者信息
Champion M C, Hartnett M, Yen M
出版信息
CMAJ. 1986 Sep 1;135(5):457-61.
Abstract
Domperidone is a dopamine antagonist that has recently been released in Canada. Unlike metoclopramide hydrochloride, the other available dopamine antagonist, it does not readily enter the central nervous system. Domperidone acts as both an antiemetic and an upper gastrointestinal tract prokinetic agent. It is rapidly absorbed after oral administration, and few side effects have been reported. Domperidone has been approved for use in Canada for the symptomatic management of upper gastrointestinal tract motility disorders and to prevent gastrointestinal symptoms associated with the use of dopamine agonist agents in Parkinson's disease. The pharmacologic features, indications and side effects of domperidone are reviewed.
摘要
多潘立酮是一种多巴胺拮抗剂，最近在加拿大上市。与另一种可用的多巴胺拮抗剂盐酸甲氧氯普胺不同，它不易进入中枢神经系统。多潘立酮兼具止吐药和上消化道促动力药的作用。口服后吸收迅速，且报道的副作用较少。多潘立酮已在加拿大获批用于上消化道动力障碍的症状性治疗，以及预防帕金森病中使用多巴胺激动剂所致的胃肠道症状。本文对多潘立酮的药理特性、适应证及副作用进行综述。
相似文献
1
Domperidone, a new dopamine antagonist.多潘立酮，一种新型多巴胺拮抗剂。
CMAJ. 1986 Sep 1;135(5):457-61.
2
[Pharmacologic and clinical differentiation of prokinetic drugs].[促动力药物的药理与临床鉴别]
Leber Magen Darm. 1996 Jul;26(4):193-8.
3
Domperidone: a peripherally acting dopamine2-receptor antagonist.多潘立酮：一种外周作用的多巴胺2受体拮抗剂。
Ann Pharmacother. 1999 Apr;33(4):429-40. doi: 10.1345/aph.18003.
4
Dopamine antagonists in the upper gastrointestinal tract.上消化道中的多巴胺拮抗剂。
Scand J Gastroenterol Suppl. 1984;96:127-36.
5
Domperidone: review of pharmacology and clinical applications in gastroenterology.多潘立酮：胃肠病学药理学与临床应用综述
Am J Gastroenterol. 2007 Sep;102(9):2036-45. doi: 10.1111/j.1572-0241.2007.01255.x. Epub 2007 May 3.
6
Making a case for domperidone in the treatment of gastrointestinal motility disorders.论证多潘立酮在治疗胃肠动力障碍中的应用
Curr Opin Pharmacol. 2006 Dec;6(6):571-6. doi: 10.1016/j.coph.2006.07.004. Epub 2006 Sep 25.
7
[Prokinetic drugs in digestive disorders].[促动力药物在消化系统疾病中的应用]
Clin Ter. 1993 Sep;143(3):219-24.
8
[Current role of antidopaminergic drugs in pediatrics].[抗多巴胺能药物在儿科中的当前作用]
Pediatr Med Chir. 2000;22(1):1-7.
9
A comparison of controlled release metoclopramide and domperidone in the treatment of nausea and vomiting.控释甲氧氯普胺与多潘立酮治疗恶心和呕吐的比较
Br J Clin Pract. 1991 Winter;45(4):247-51.
10
Prokinetic therapy for gastroesophageal reflux disease.胃食管反流病的促动力治疗
Am Fam Physician. 1995 Sep 1;52(3):957-62, 965-6.
引用本文的文献
1
Domperidone inhibits cell proliferation via targeting MEK and CDK4 in esophageal squamous cell carcinoma.多潘立酮通过靶向食管鳞状细胞癌中的MEK和CDK4抑制细胞增殖。
Cancer Cell Int. 2024 Mar 25;24(1):114. doi: 10.1186/s12935-024-03291-8.
2
Receptor-Mediated AKT/PI3K Signalling and Behavioural Alterations in Zebrafish Larvae Reveal Association between Schizophrenia and Opioid Use Disorder.受体介导的 AKT/PI3K 信号转导与斑马鱼幼鱼行为改变揭示精神分裂症与阿片类药物使用障碍的关联。
Int J Mol Sci. 2022 Apr 25;23(9):4715. doi: 10.3390/ijms23094715.
3
Acquired long QT syndrome due to antiemetics, COVID-19 and induced exacerbation of congenital chloride losing diarrhoea.因止吐药、COVID-19 以及由此引发的先天性氯离子丢失性腹泻加重导致获得性长 QT 综合征。
BMJ Case Rep. 2022 Apr 26;15(4):e246175. doi: 10.1136/bcr-2021-246175.
4
The pharmacokinetics of oral trazpiroben (TAK-906) after organic anion transporting polypeptide 1B1/1B3 inhibition: A phase I, randomized study.口服曲匹布通（TAK-906）在有机阴离子转运多肽 1B1/1B3 抑制后的药代动力学：一项 I 期、随机研究。
Clin Transl Sci. 2022 Jun;15(6):1532-1543. doi: 10.1111/cts.13274. Epub 2022 May 5.
5
A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research.治疗恶心和呕吐的药物发现史及其对未来研究的启示
Front Pharmacol. 2018 Sep 4;9:913. doi: 10.3389/fphar.2018.00913. eCollection 2018.
6
Omeprazole-Domperidone Fixed Dose Combination vs Omeprazole Monotherapy: A Phase 4, Open-Label, Comparative, Parallel Randomized Controlled Study in Mild to Moderate Gastroesophageal Reflux Disease.奥美拉唑-多潘立酮固定剂量复方制剂与奥美拉唑单药治疗对比：一项针对轻至中度胃食管反流病的4期、开放标签、比较性、平行随机对照研究。
Clin Med Insights Gastroenterol. 2017 May 31;10:1179552217709456. doi: 10.1177/1179552217709456. eCollection 2017.
7
Current use of domperidone and co-prescribing of medications that increase its arrhythmogenic potential among older adults: a population-based cohort study in Ontario, Canada.多潘立酮的当前使用情况以及老年人中增加其致心律失常风险的药物联合处方情况：加拿大安大略省一项基于人群的队列研究。
Drugs Aging. 2014 Nov;31(11):805-13. doi: 10.1007/s40266-014-0215-z.
8
Domperidone effective in preventing rivastigmine-related gastrointestinal disturbances in patients with Alzheimer's disease.多潘立酮可有效预防阿尔茨海默病患者瑞伐他汀相关的胃肠道紊乱。
Neuropsychiatr Dis Treat. 2013;9:1411-5. doi: 10.2147/NDT.S50135. Epub 2013 Sep 18.
9
Effect of ursodeoxycholic Acid alone and ursodeoxycholic Acid plus domperidone on radiolucent gallstones and gallbladder contractility in humans.熊去氧胆酸单独和熊去氧胆酸加多潘立酮对人透光性胆囊结石和胆囊收缩功能的影响。
Gastroenterol Res Pract. 2012;2012:159438. doi: 10.1155/2012/159438. Epub 2012 May 7.
10
Clinical review and treatment of select adverse effects of dopamine receptor agonists in Parkinson's disease.帕金森病中多巴胺受体激动剂相关不良反应的临床评估和治疗。
Drugs Aging. 2010 Apr 1;27(4):295-310. doi: 10.2165/11318330-000000000-00000.
本文引用的文献
1
Bromocriptine and domperidone in the treatment of Parkinson disease.溴隐亭与多潘立酮治疗帕金森病
Neurology. 1981 Jun;31(6):662-7. doi: 10.1212/wnl.31.6.662.
2
Double-blind evaluation of domperidone in acute vomiting and dyspeptic disorders.
J Int Med Res. 1981;9(2):143-7. doi: 10.1177/030006058100900211.
3
Domperidone. A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic.多潘立酮。对其药理活性、药代动力学以及在慢性消化不良症状治疗和作为止吐药方面的治疗效果的综述。
Drugs. 1982 Nov;24(5):360-400. doi: 10.2165/00003495-198224050-00002.
4
Diabetic gastroparesis: treatment with domperidone--a double-blind, placebo-controlled trial.
Digestion. 1983;27(4):214-7. doi: 10.1159/000198955.
5
Acute extrapyramidal dysfunction after domperidone administration. Report of a case.
Helv Paediatr Acta. 1984 Aug;39(3):285-8.
6
Domperidone and levodopa in Parkinson's disease.多潘立酮与左旋多巴治疗帕金森病
Br J Clin Pharmacol. 1984 Dec;18(6):959-62. doi: 10.1111/j.1365-2125.1984.tb02571.x.
7
Metoclopramide: pharmacology and clinical application.甲氧氯普胺：药理学与临床应用
Ann Intern Med. 1983 Jan;98(1):86-95. doi: 10.7326/0003-4819-98-1-86.
8
Review of the current status of prokinetic agents in gastroenterology.胃肠病学中促动力药物的现状综述
Am J Gastroenterol. 1985 Dec;80(12):1008-16.
9
Effects of domperidone therapy on symptoms and upper gastrointestinal motility in infants with gastroesophageal reflux.
J Pediatr. 1985 Feb;106(2):311-6. doi: 10.1016/s0022-3476(85)80315-2.
10
Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy.多潘立酮对糖尿病自主神经病变患者胃排空的急慢性影响
Dig Dis Sci. 1985 Jan;30(1):1-9. doi: 10.1007/BF01318363.
Zotero 插件