Balmain N, Brehier A, Cuisinier-Gleizes P, Mathieu H
Cell Tissue Res. 1986;245(2):331-5. doi: 10.1007/BF00213939.
The distribution of the vitamin-D dependent calcium-binding protein (Calbindin-D 28K) (CaBP-28K) in the tibial growth plate cartilage of the rat has been studied immunohistochemically using an antibody raised against rat renal CaBP-28K. The protein was detected mainly in the nuclei of chondrocytes and occasionally in the juxtanuclear cytoplasm. The distribution was not uniform throughout the growth plate, but concentrated in the proliferatively active chondrocytes of the resting and proliferative zones. These findings raise the possibility that CaBP-28K may be involved in the mitotic activity of the chondrocytes, acting as a regulator of the proliferative process, perhaps via intranuclear calcium.
利用针对大鼠肾钙结合蛋白-28K（CaBP-28K）产生的抗体，通过免疫组织化学方法研究了维生素D依赖性钙结合蛋白（钙结合蛋白-D 28K，CaBP-28K）在大鼠胫骨生长板软骨中的分布。该蛋白主要在软骨细胞核中检测到，偶尔也在近核细胞质中检测到。其分布在整个生长板中并不均匀，而是集中在静止区和增殖区增殖活跃的软骨细胞中。这些发现提示，CaBP-28K可能参与软骨细胞的有丝分裂活动，也许通过核内钙作为增殖过程的调节因子。
