一名年轻免疫功能正常的 COVID-19 患者粪便中长期排出 SARS-CoV-2:病例报告及文献综述。
Prolonged fecal shedding of SARS-CoV-2 in a young immunocompetent COVID-19 patient: A case report and literature overview.
机构信息
Department of Infectious Disease, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Department of Infectious Disease, Guangxi Duan Yao Autonomous County People's Hospital, Hechi, China.
出版信息
J Med Virol. 2022 Jul;94(7):3133-3137. doi: 10.1002/jmv.27694. Epub 2022 Mar 22.
Clinicians are facing several challenges in tackling coronavirus disease 2019 (COVID-19); one issue is prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA. Here, we describe a case of SARS-CoV-2 infection in a young immunocompetent patient with a virological course lasting for 71 days. Following antiviral treatment, but no additional glucocorticoid or interferon therapy, the patient recovered from COVID-19 pneumonia (moderate). Detection of viral RNA via throat swabs showed negative results. However, the viral RNA reappeared and persisted in stool samples for an additional 27 days, while the patient remained asymptomatic and exhibited no abnormal signs. This case indicates that SARS-CoV-2 can result in a prolonged fecal RNA shedding, even in an immunocompetent patient with zero exposure to immunosuppressive therapies.
临床医生在应对 2019 年冠状病毒病(COVID-19)时面临着一些挑战;其中一个问题是严重急性呼吸综合征冠状病毒 2(SARS-CoV-2)RNA 的持续检测。在这里,我们描述了一例发生在年轻免疫功能正常患者中的 SARS-CoV-2 感染病例,其病毒学过程持续了 71 天。在接受抗病毒治疗后,但未接受额外的糖皮质激素或干扰素治疗后,该患者从 COVID-19 肺炎(中度)中康复。通过咽喉拭子检测到病毒 RNA 呈阴性结果。然而,病毒 RNA 再次出现并在粪便样本中持续存在了 27 天,而患者仍无症状,且无异常迹象。该病例表明,SARS-CoV-2 可导致粪便 RNA 持续排出,即使是在未接触免疫抑制治疗的免疫功能正常的患者中也是如此。
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