Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Clinical Laboratory, Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China.
J Med Virol. 2020 Sep;92(9):1681-1683. doi: 10.1002/jmv.25940. Epub 2020 Jun 2.
As an emerging infectious disease, the clinical course and virological course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain to be further investigated. In this case report, we described a case of SARS-CoV-2 infection with the clinical course for more than 2 months. This patient had recovered from pneumonia after treatment. The viral RNA of throat swabs became negative and the viral-specific antibodies were produced during the recovery period. However, the viral RNA reappeared and additionally persisted in throat swabs for more than 40 days. In addition, the viral RNA was detected in multiple types of specimens with extremely high titers in the saliva. In conclusion, these findings indicate that SARS-CoV-2 can cause a long clinical course. The coexistence of viral RNA and viral-specific antibodies may imply an immune evasion of SARS-CoV-2 from the host's immune system.
作为一种新兴的传染病，严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染的临床和病毒学过程仍需进一步研究。在本病例报告中，我们描述了一例临床病程超过 2 个月的 SARS-CoV-2 感染病例。该患者经治疗后肺炎痊愈，恢复期咽拭子病毒 RNA 转为阴性并产生了病毒特异性抗体。然而，病毒 RNA 再次出现并在咽拭子中持续存在超过 40 天。此外，在唾液中多种类型的标本中均检测到病毒 RNA，且病毒载量极高。总之，这些发现表明 SARS-CoV-2 可引起较长的临床病程。病毒 RNA 与病毒特异性抗体共存可能提示 SARS-CoV-2 逃避了宿主免疫系统的免疫清除。
