Melatonin increased hypoxia-inducible factor (HIF) by inhibiting prolyl hydroxylase: A hypothesis for treating anaemia, ischaemia, and covid-19.
作者信息
Hosseinzadeh Mohammad Hossein, Goodarzi Amin, Malekan Mohammad, Ebrahimzadeh Mohammad Ali
机构信息
Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
出版信息
Clin Exp Pharmacol Physiol. 2022 Jun;49(6):696-698. doi: 10.1111/1440-1681.13639. Epub 2022 Mar 25.
Abstract
摘要
相似文献
1
Melatonin increased hypoxia-inducible factor (HIF) by inhibiting prolyl hydroxylase: A hypothesis for treating anaemia, ischaemia, and covid-19.褪黑素通过抑制脯氨酰羟化酶增加缺氧诱导因子（HIF）：一种治疗贫血、缺血和新冠病毒病的假说
Clin Exp Pharmacol Physiol. 2022 Jun;49(6):696-698. doi: 10.1111/1440-1681.13639. Epub 2022 Mar 25.
2
Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications.缺氧诱导因子脯氨酰羟化酶抑制剂开发的最新进展及其治疗意义
Molecules. 2015 Nov 19;20(11):20551-68. doi: 10.3390/molecules201119717.
3
Changes in Hypoxia-Inducible Factor-1 (HIF-1) and Regulatory Prolyl Hydroxylase (PHD) Enzymes Following Hypoxic-Ischemic Injury in the Neonatal Rat.新生大鼠缺氧缺血性损伤后缺氧诱导因子-1（HIF-1）和调节性脯氨酰羟化酶（PHD）的变化
Neurochem Res. 2016 Mar;41(3):515-22. doi: 10.1007/s11064-015-1641-y. Epub 2015 Jun 25.
4
2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2.2-氧代戊二酸调节羟基化缺氧诱导因子与脯氨酰羟化酶结构域2的结合。
Chem Commun (Camb). 2018 Mar 28;54(25):3130-3133. doi: 10.1039/c8cc00387d. Epub 2018 Mar 9.
5
Hypoxia-inducible factor prolyl 4-hydroxylase inhibition in cardiometabolic diseases.缺氧诱导因子脯氨酰4-羟化酶抑制在心脏代谢疾病中的作用
Pharmacol Res. 2016 Dec;114:265-273. doi: 10.1016/j.phrs.2016.11.003. Epub 2016 Nov 8.
6
Protein Hydroxylation by Hypoxia-Inducible Factor (HIF) Hydroxylases: Unique or Ubiquitous?缺氧诱导因子 (HIF) 羟化酶介导的蛋白质羟化：独特还是普遍存在？
Cells. 2019 Apr 26;8(5):384. doi: 10.3390/cells8050384.
7
Prolyl hydroxylase inhibition protects the kidneys from ischemia via upregulation of glycogen storage.脯氨酰羟化酶抑制通过上调糖原储存保护肾脏免受缺血损伤。
Kidney Int. 2020 Apr;97(4):687-701. doi: 10.1016/j.kint.2019.10.020. Epub 2019 Nov 9.
8
Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells.穿心莲内酯通过激活Nrf2/HO-1并促进脯氨酰羟化酶2/3在人内皮细胞中的表达，抑制缺氧诱导的HIF-1α驱动的内皮素1分泌。
Environ Toxicol. 2017 Mar;32(3):918-930. doi: 10.1002/tox.22293. Epub 2016 Jun 14.
9
miR-190 Enhances HIF-Dependent Responses to Hypoxia in Drosophila by Inhibiting the Prolyl-4-hydroxylase Fatiga.微小RNA-190通过抑制脯氨酰-4-羟化酶Fatiga增强果蝇中低氧诱导因子依赖的低氧反应。
PLoS Genet. 2016 May 25;12(5):e1006073. doi: 10.1371/journal.pgen.1006073. eCollection 2016 May.
10
Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation.硒蛋白2通过AMPK介导的脯氨酰羟化酶调节来抑制缺氧诱导因子-1α的积累。
Free Radic Biol Med. 2016 Dec;101:511-523. doi: 10.1016/j.freeradbiomed.2016.11.014. Epub 2016 Nov 11.
本文引用的文献
1
Efficacy of melatonin in the treatment of patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials.褪黑素治疗 COVID-19 患者的疗效：随机对照试验的系统评价和荟萃分析。
J Med Virol. 2022 May;94(5):2102-2107. doi: 10.1002/jmv.27595. Epub 2022 Jan 23.
2
Efficacy and Safety of Molidustat for Anemia in ESA-Naive Nondialysis Patients: A Randomized, Phase 3 Trial.莫立司他治疗 ESA-初治非透析患者贫血的疗效和安全性：一项随机、3 期临床试验。
Am J Nephrol. 2021;52(10-11):871-883. doi: 10.1159/000518071. Epub 2021 Sep 16.
3
Melatonin effects on sleep quality and outcomes of COVID-19 patients: An open-label, randomized, controlled trial.褪黑素对 COVID-19 患者睡眠质量和结局的影响：一项开放标签、随机、对照试验。
J Med Virol. 2022 Jan;94(1):263-271. doi: 10.1002/jmv.27312. Epub 2021 Sep 8.
4
Efficacy of a Low Dose of Melatonin as an Adjunctive Therapy in Hospitalized Patients with COVID-19: A Randomized, Double-blind Clinical Trial.褪黑素低剂量作为 COVID-19 住院患者辅助治疗的疗效：一项随机、双盲临床试验。
Arch Med Res. 2022 Jan;53(1):79-85. doi: 10.1016/j.arcmed.2021.06.006. Epub 2021 Jun 23.
5
The role of Hypoxia-Inducible Factor-1alpha and its signaling in melanoma.缺氧诱导因子-1α及其信号通路在黑色素瘤中的作用。
Biomed Pharmacother. 2021 Sep;141:111873. doi: 10.1016/j.biopha.2021.111873. Epub 2021 Jul 2.
6
Melatonin, Its Beneficial Effects on Embryogenesis from Mitigating Oxidative Stress to Regulating Gene Expression.褪黑素，其对胚胎发育的有益作用——从减轻氧化应激到调节基因表达。
Int J Mol Sci. 2021 May 30;22(11):5885. doi: 10.3390/ijms22115885.
7
HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review.缺氧诱导因子-α脯氨酰羟化酶抑制剂及其在生物医学中的意义：综述
Biomedicines. 2021 Apr 24;9(5):468. doi: 10.3390/biomedicines9050468.
8
Safety and Efficacy of Vadadustat for Anemia in Patients Undergoing Dialysis.维达列汀治疗透析患者贫血的安全性和疗效。
N Engl J Med. 2021 Apr 29;384(17):1601-1612. doi: 10.1056/NEJMoa2025956.
9
HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons.用于治疗新冠病毒肺炎的低氧诱导因子脯氨酰羟化酶抑制剂：利弊
Front Pharmacol. 2021 Jan 29;11:621054. doi: 10.3389/fphar.2020.621054. eCollection 2020.
10
Roxadustat for Treating Anemia in Patients with CKD Not on Dialysis: Results from a Randomized Phase 3 Study.罗沙司他治疗未透析慢性肾脏病患者贫血的随机 3 期研究结果。
J Am Soc Nephrol. 2021 Mar;32(3):737-755. doi: 10.1681/ASN.2020081150. Epub 2021 Feb 10.
Zotero 插件