Clinical research is critical to developing new treatments and therapies for patients. To maximize societal benefit and health equity, it is important that clinical research information be accessible and inclusive, and participants should be representative of the patient population. To explore the role that patient comprehension of clinical research can have in delivering high-quality clinical care and in increasing the diversity of the populations enrolled in clinical research, the National Academies of Sciences, Engineering, and Medicine’s Roundtable on Health Literacy held a virtual public workshop on October 28, 2021. Workshop attendees discussed current and promising resources and approaches for ensuring that the public receives clinical research information in accessible language that promotes health literacy. They also discussed strategies for integrating clinical research information into various care and community settings to improve research awareness and engagement. This Proceedings of a Workshop-in Brief highlights the presentations and discussions of the workshop.