可吸入粉尘和二氧化硅：瑞典铸造厂工人的呼吸道疾病。
Respirable Dust and Silica: Respiratory Diseases Among Swedish Iron Foundry Workers.
机构信息
From the Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Lenander-Ramirez, Bryngelsson, Westberg, and Dr Andersson); Geriatic Clinic, Faculty of Medicine and Health, Örebro University, Örebro Sweden (Dr Vihlborg); School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden (Westberg and Dr Andersson).
出版信息
J Occup Environ Med. 2022 Jul 1;64(7):593-598. doi: 10.1097/JOM.0000000000002533. Epub 2022 Mar 11.
OBJECTIVE
The mortality and morbidity pattern for respiratory diseases was determined in a cohort of 1752 Swedish foundry workers, particularly for respirable silica dust exposure.
METHODS
The morbidity follow-up in the Swedish National Non-primary Outpatient Register covered 2001 to 2017 (NPR; specialist not in care patients), the mortality from the National Causes of Death Register covered 2001 to 2017. Cumulative exposures to silica and dust were determined.
RESULTS
The morbidity in COPD showed significantly increased risk for all exposure groups, as did silicosis in the high exposure group, these cases corresponded to silica exposure levels below 0.05 mg/m3. The mortality of all causes and respiratory diseases was significantly increased by cumulative silica exposure in the high exposure group.
CONCLUSIONS
Significantly increased morbidity for respiratory diseases and COPD was determined at silica exposure levels below the current Swedish OEL.
目的
在 1752 名瑞典铸造厂工人队列中确定了呼吸系统疾病的死亡率和发病率模式，特别是针对可吸入二氧化硅粉尘暴露。
方法
瑞典国家非初级门诊登记处（NPR；未在护理患者的专科医生）对 2001 年至 2017 年的发病率进行了随访，国家死因登记处对 2001 年至 2017 年的死亡率进行了随访。确定了二氧化硅和粉尘的累积暴露量。
结果
COPD 的发病率在所有暴露组均显示出显著增加的风险，高暴露组的矽肺也是如此，这些病例对应的是二氧化硅暴露水平低于 0.05 毫克/立方米。高暴露组的累积二氧化硅暴露与所有原因和呼吸系统疾病的死亡率显著增加有关。
结论
在低于当前瑞典 OEL 的二氧化硅暴露水平下，确定了呼吸系统疾病和 COPD 的发病率显著增加。
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