Lee Siew Siew, McGrattan Andrea, Soh Yee Chang, Alawad Mawada, Su Tin Tin, Palanisamy Uma Devi, Hussin Azizah Mat, Kassim Zaid Bin, Mohd Ghazali Ahmad Nizal Bin, Christa Maree Stephan Blossom, Allotey Pascale, Reidpath Daniel D, Robinson Louise, Mohan Devi, Siervo Mario
Global Public Health, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Malaysia.
School of Biomedical, Nutritional and Sports Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Nutrients. 2022 Jan 19;14(3):430. doi: 10.3390/nu14030430.
The DePEC-Nutrition trial is a complex dietary and behavioural intervention of salt intake reduction combined with increased high-nitrate vegetable consumption among Malaysian middle-aged and older adults with elevated blood pressure. This study aimed to assess the feasibility and acceptability of the trial. Participants were recruited from the South East Asia Community Observatory (SEACO) database and randomised into one of four groups: (1) low salt; (2) high-nitrate vegetable; (3) combined high-nitrate vegetable and low salt; and (4) control. The intervention included a combination of group counselling sessions, information booklets, reinforcement videos and text messages to modify dietary behaviour. The primary outcomes evaluated were the measures of feasibility and acceptability of (1) recruitment, follow-up attendance and retention; (2) data collection procedures and clinical outcome measures; and (3) individual and combined multi-modal dietary interventions. A total of 74 participants were recruited, and the 10-month retention rate was 73%. Data collection procedures were acceptable with minimal missing data. All intervention strategies were feasible and acceptable, with group counselling being the most acceptable strategy. This study provides important insights into improving the screening process of participants, facilitating their access to the research facilities and refining the measurement protocols and dietary recommendations, which are instrumental in formulating the design of a full-scale definitive DePEC-Nutrition trial.
DePEC-营养试验是一项针对马来西亚血压升高的中老年人的复杂饮食和行为干预措施，包括减少盐摄入量以及增加高硝酸盐蔬菜的摄入量。本研究旨在评估该试验的可行性和可接受性。参与者从东南亚社区观察站（SEACO）数据库中招募，并随机分为四组之一：（1）低盐组；（2）高硝酸盐蔬菜组；（3）高硝酸盐蔬菜与低盐联合组；（4）对照组。干预措施包括小组咨询会议、信息手册、强化视频和短信相结合，以改变饮食行为。评估的主要结果是以下方面的可行性和可接受性指标：（1）招募、随访出勤率和留存率；（2）数据收集程序和临床结果指标；（3）个体和联合多模式饮食干预措施。共招募了74名参与者，10个月的留存率为73%。数据收集程序可以接受，缺失数据极少。所有干预策略都是可行且可接受的，其中小组咨询是最可接受的策略。本研究为改进参与者的筛选过程、方便他们使用研究设施以及完善测量方案和饮食建议提供了重要见解，这些对于制定全面的确定性DePEC-营养试验设计至关重要。
