Leboyer M
Encephale. 1986 Mar-Apr;12(2):45-62.
This article gives an overview of the biochemistry, physiology and pharmacology of endogenous opioid peptides. The role of endorphins in psychiatric pathology in the last ten years, has mainly been studied through two clinical research strategies: Pharmacological, administration of opiate agonists or antagonists, or substances altering endorphins metabolism. Biological, static or dynamic dosage of opioid activity in peripheral liquids, trying to correlate those measures either with a syndrome, or with a clinical trait. These methods applied to schizophrenia, affective disorders, anxiety, addiction, anorexia, and tardive dyskinesia are being reviewed. Results are very heterogeneous but support the involvement of the endogenous opioid system in some psychiatric pathology. Furthermore, this paper should help to underline some of the present day development of biological psychiatry.
本文概述了内源性阿片肽的生物化学、生理学和药理学。在过去十年中，内啡肽在精神病理学中的作用主要通过两种临床研究策略进行了研究：药理学方面，使用阿片类激动剂或拮抗剂，或改变内啡肽代谢的物质；生物学方面，对外周液体中的阿片类活性进行静态或动态定量，试图将这些测量结果与某种综合征或临床特征联系起来。本文对应用于精神分裂症、情感障碍、焦虑症、成瘾、厌食症和迟发性运动障碍的这些方法进行了综述。结果差异很大，但支持内源性阿片系统参与某些精神病理学过程。此外，本文有助于强调当今生物精神病学的一些发展。
