School of Pharmacy and Medical Sciences, Griffith University, Gold Coast Campus, Southport, QLD 4215, Australia.
Nutrients. 2022 Jan 31;14(3):628. doi: 10.3390/nu14030628.
Selenium is an essential trace element required for human health, and selenium deficiency has been associated with many diseases. The daily recommended intake of selenium is 60 µg/day for adults, which increases to 65 µg/day for women when pregnant. Selenium is incorporated into the 21st amino acid, selenocysteine (sec), a critical component of selenoproteins that plays an important role in a variety of biological responses such as antioxidant defence, reactive oxygen species (ROS) signalling, formation of thyroid hormones, DNA synthesis and the unfolded protein response in the endoplasmic reticulum (ER). Although 25 selenoproteins have been identified, the role of many of these is yet to be fully characterised. This review summarises the current evidence demonstrating that selenium is essential for a healthy pregnancy and that poor selenium status leads to gestational disorders. In particular, we focus on the importance of the placental selenoproteome, and the role these proteins may play in a healthy start to life.
硒是人体健康所必需的微量元素，硒缺乏与许多疾病有关。成年人每天推荐的硒摄入量为 60μg，孕妇每天的推荐摄入量增加到 65μg。硒被纳入第 21 个氨基酸——硒代半胱氨酸（sec），这是硒蛋白的关键组成部分，在多种生物反应中发挥着重要作用，如抗氧化防御、活性氧（ROS）信号、甲状腺激素的形成、DNA 合成以及内质网（ER）中的未折叠蛋白反应。尽管已经确定了 25 种硒蛋白，但其中许多的作用仍有待充分阐明。这篇综述总结了目前的证据，表明硒对健康妊娠至关重要，而硒缺乏状态会导致妊娠障碍。特别是，我们重点关注胎盘硒蛋白组的重要性，以及这些蛋白质在健康人生开端中可能发挥的作用。
