Servicio de Reumatología, Hospital Universitari i Politècnic La Fe, Valencia, Spain; Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain.
Servicio de Reumatología, Hospital Universitari i Politècnic La Fe, Valencia, Spain; Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain; Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.
Med Clin (Barc). 2022 Nov 25;159(10):470-474. doi: 10.1016/j.medcli.2022.01.017. Epub 2022 Mar 8.
BACKGROUND/OBJECTIVE: To assess the Cardiovascular Risk (CV) in Rheumatoid Arthritis (RA) patients using carotid ultrasound additionally to the traditional CV risk factors.
A cross-sectional case control study was performed including RA patients and matched controls. This study was performed from July-2019 to January-2020. Population over 75 years old, established CV disease and/or chronic kidney disease (from III Stage) were excluded. Statistical analysis included a multivariate variance analysis (Manova) and a negative binomial regression adjusted by confounding factors.
Overall, a total of 200 cases and 111 controls were included in the study. Demographical and clinical variables were comparable between groups. A relationship between age, BMI and high blood pressure was detected in both groups. RA patients showed higher intima-media thickness and higher plaque account compared to controls and it was related to the disease duration and DAS28 score.
RA leads to a higher intima-media thickness, and this is related to the disease duration and DAS28 score. These findings support that RA acts as an independent cardiovascular risk factor.
背景/目的：通过颈动脉超声评估类风湿关节炎（RA）患者的心血管风险（CV），并结合传统 CV 危险因素。
本研究为一项横断面病例对照研究，纳入 RA 患者和匹配对照。该研究于 2019 年 7 月至 2020 年 1 月进行。排除年龄超过 75 岁、已确诊 CV 疾病和/或慢性肾脏病（III 期）的患者。统计分析包括多元方差分析（Manova）和调整混杂因素的负二项式回归。
本研究共纳入 200 例病例和 111 例对照。两组间人口统计学和临床变量无显著差异。两组中均发现年龄、BMI 和高血压之间存在相关性。与对照组相比，RA 患者的内膜中层厚度和斑块积分更高，且与疾病持续时间和 DAS28 评分相关。
RA 导致内膜中层厚度增加，且与疾病持续时间和 DAS28 评分相关。这些发现支持 RA 是一种独立的心血管危险因素。
