类风湿关节炎的颈动脉超声心血管风险评估。

Cardiovascular risk assessment with carotid ultrasound in rheumatoid arthritis.

机构信息

Servicio de Reumatología, Hospital Universitari i Politècnic La Fe, Valencia, Spain; Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain.

Servicio de Reumatología, Hospital Universitari i Politècnic La Fe, Valencia, Spain; Escuela de Doctorado, Universidad Católica de Valencia San Vicente Mártir, Valencia, Spain; Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.

出版信息

Med Clin (Barc). 2022 Nov 25;159(10):470-474. doi: 10.1016/j.medcli.2022.01.017. Epub 2022 Mar 8.

DOI:10.1016/j.medcli.2022.01.017

PMID:35277271

Abstract

BACKGROUND/OBJECTIVE: To assess the Cardiovascular Risk (CV) in Rheumatoid Arthritis (RA) patients using carotid ultrasound additionally to the traditional CV risk factors.

METHODS

A cross-sectional case control study was performed including RA patients and matched controls. This study was performed from July-2019 to January-2020. Population over 75 years old, established CV disease and/or chronic kidney disease (from III Stage) were excluded. Statistical analysis included a multivariate variance analysis (Manova) and a negative binomial regression adjusted by confounding factors.

RESULTS

Overall, a total of 200 cases and 111 controls were included in the study. Demographical and clinical variables were comparable between groups. A relationship between age, BMI and high blood pressure was detected in both groups. RA patients showed higher intima-media thickness and higher plaque account compared to controls and it was related to the disease duration and DAS28 score.

CONCLUSION

RA leads to a higher intima-media thickness, and this is related to the disease duration and DAS28 score. These findings support that RA acts as an independent cardiovascular risk factor.

摘要

背景/目的：通过颈动脉超声评估类风湿关节炎（RA）患者的心血管风险（CV），并结合传统 CV 危险因素。