评估青少年特发性关节炎患者的心血管危险因素。
Assessment of Cardiovascular Risk Factors in Patients with Juvenile Idiopathic Arthritis.
机构信息
Department of Pediatric Cardiology and Rheumatology, Medical University of Lodz, Sporna 36/50, 91-738 Lodz, Poland.
Institute of Information Technology, Lodz University of Technology, 91-738 Lodz, Poland.
出版信息
Nutrients. 2023 Mar 30;15(7):1700. doi: 10.3390/nu15071700.
INTRODUCTION
The aim of this study was to assess the exposure to cardiovascular disease (CVD) risk factors in patients with juvenile idiopathic arthritis (JIA). Intima-media complex thickness (IMT), selected metabolic parameters and health behaviors were assessed in the course of the study.
METHODS
The study included study group, which consisted of 45 patients with JIA and 37 healthy age- and sex-matched children in the control group. Analyses in both groups included anthropometric parameters, laboratory tests, IMT and a questionnaire on exposure to modifiable CVD risk factors.
RESULTS
The study confirmed that CVD risk factors were present in both groups of patients. Significantly more children with JIA had abnormal BMI ( = 0.006) compared to the control group. Children in the study group were more likely to consume fruit regularly ( = 0.021) and less likely to consume fast food ( = 0.011) and sweetened beverages ( = 0.042) than children in the control group. Only 1 patient with JIA met criteria for ideal cardiovascular health. Dietary habits were not associated with IMT values, BMI, presence of joint pain or biochemical parameters in the study group.
CONCLUSIONS
Patients with JIA are exposed to cardiovascular risk factors equally to their healthy peers. Ideal cardiovascular health should be pursued in the pediatric population with particular attention paid to patients with chronic diseases (i.e., JIA). The application of carotid artery IMT measurement in the assessment of CVD risk requires studies on a larger group of patients.
简介
本研究旨在评估青少年特发性关节炎（JIA）患者心血管疾病（CVD）风险因素的暴露情况。在研究过程中评估了动脉内膜中层厚度（IMT）、选定的代谢参数和健康行为。
方法
研究包括研究组，其中包括 45 名 JIA 患者和 37 名年龄和性别匹配的健康对照组儿童。两组的分析均包括人体测量参数、实验室检查、IMT 和暴露于可改变的 CVD 风险因素的问卷。
结果
研究证实，两组患者均存在 CVD 风险因素。与对照组相比，患有 JIA 的儿童中 BMI 异常的明显更多（ = 0.006）。研究组的儿童更有可能定期食用水果（ = 0.021），而不太可能食用快餐（ = 0.011）和甜饮料（ = 0.042）。只有 1 名 JIA 患者符合理想心血管健康标准。饮食习惯与 IMT 值、BMI、关节疼痛或研究组的生化参数无关。
结论
JIA 患者与健康同龄人一样面临心血管风险因素。应在儿科人群中追求理想的心血管健康，特别关注患有慢性疾病（即 JIA）的患者。颈动脉 IMT 测量在 CVD 风险评估中的应用需要对更多患者进行研究。
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