Farag Mena, Bahra Anish
The National Hospital for Neurology & Neurosurgery (NHNN), London, UK.
Department of Neurology, Barts Health NHS Trust, Whipps Cross Hospital, London, UK.
Headache. 2022 Mar;62(3):383-388. doi: 10.1111/head.14282. Epub 2022 Mar 12.
Indomethacin-responsive headaches encompass a group of disorders which include a subset of the trigeminal autonomic cephalalgias and other paroxysmal, often precipitated primary headaches. Many patients show a rapid therapeutic response to indomethacin, which is limited by intolerability. Etoricoxib and celecoxib, selective inhibitors of cyclo-oxygenase-2 (COX-2), spare gastroduodenal COX-1 activity and are less likely to cause gastrointestinal adverse effects than indomethacin. We report a case series of eight patients, seven who responded to etoricoxib and one patient who responded to celecoxib.
吲哚美辛反应性头痛包括一组疾病，其中包括三叉神经自主性头痛的一个子集以及其他阵发性、常由诱因引发的原发性头痛。许多患者对吲哚美辛表现出快速的治疗反应，但这种反应因耐受性问题而受到限制。依托考昔和塞来昔布是环氧化酶-2（COX-2）的选择性抑制剂，可保留胃十二指肠COX-1活性，且与吲哚美辛相比，引起胃肠道不良反应的可能性较小。我们报告了一组8例患者的病例系列，其中7例对依托考昔有反应，1例对塞来昔布有反应。
