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Cox-2 抑制剂是否为吲哚美辛反应性头痛的二线选择？

Are Cox-2 drugs the second line option in indomethacin responsive headaches?

机构信息

Headache Unit, Hospital Universitario Clínico San Carlos, C/ Andrés Torrejón 15, Madrid, Spain.

出版信息

J Headache Pain. 2010 Oct;11(5):405-7. doi: 10.1007/s10194-010-0225-0. Epub 2010 Jun 2.

DOI:10.1007/s10194-010-0225-0
PMID:20517705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3452276/
Abstract

Paroxysmal hemicrania and hemicrania continua are both indomethacin-responsive headaches. Although indomethacin use to be well tolerated, some patients developed gastrointestinal side effects. We report four cases of hemicrania continua and a patient suffering chronic paroxysmal hemicrania completely responsive to celecoxib. In our experience celecoxib is a good option treatment for patients suffering from hemicrania continua or chronic paroxysmal hemicranea that presents indomethacin adverse effects.

摘要

发作性偏头痛和连续性偏头痛均对吲哚美辛有反应。虽然吲哚美辛的应用一直耐受良好，但一些患者出现了胃肠道副作用。我们报告了 4 例连续性偏头痛和 1 例慢性发作性偏头痛患者，他们对塞来昔布完全有反应。根据我们的经验，塞来昔布是治疗因吲哚美辛不良反应而出现连续性偏头痛或慢性发作性偏头痛的患者的一种较好的选择。

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Paroxysmal Hemicrania.阵发性偏侧头痛
Ann Indian Acad Neurol. 2018 Apr;21(Suppl 1):S16-S22. doi: 10.4103/aian.AIAN_317_17.
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本文引用的文献

1
Focus on therapy of primary stabbing headache.专注原发性刺痛头痛的治疗。
J Headache Pain. 2010 Apr;11(2):157-60. doi: 10.1007/s10194-010-0189-0. Epub 2010 Jan 30.
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Primary stabbing headache can be responsive to etoricoxib, a selective COX-2 inhibitor.
Eur J Neurol. 2008 Jan;15(1):e1. doi: 10.1111/j.1468-1331.2007.01962.x.
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The use of etoricoxib to treat an idiopathic stabbing headache: a case report.依托考昔治疗特发性刺痛性头痛：一例报告。
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4
Seasonal episodic paroxysmal hemicrania responding to cyclooxygenase-2 inhibitors.对环氧化酶-2抑制剂有反应的季节性发作性阵发性偏侧头痛
Cephalalgia. 2004 May;24(5):414-5. doi: 10.1111/j.1468-2982.2003.00695.x.
5
Rofecoxib for the treatment of chronic paroxysmal hemicrania.罗非昔布用于治疗慢性阵发性偏侧头痛。
Cephalalgia. 2003 May;23(4):318-20. doi: 10.1046/j.1468-2982.2003.00500.x.
6
Hemicrania continua responds to cyclooxygenase-2 inhibitors.持续性偏头疼对环氧化酶-2抑制剂有反应。
Headache. 2002 Jun;42(6):530-1. doi: 10.1046/j.1526-4610.2002.02131.x.
7
COX-2 inhibitor for the treatment of idiopathic stabbing headache secondary to cerebrovascular diseases.用于治疗继发于脑血管疾病的特发性刺痛性头痛的环氧化酶-2抑制剂。
Cephalalgia. 2002 Apr;22(3):197-200. doi: 10.1046/j.1468-2982.2002.00346.x.
8
Dose, efficacy and tolerability of long-term indomethacin treatment of chronic paroxysmal hemicrania and hemicrania continua.
Cephalalgia. 2001 Nov;21(9):906-10. doi: 10.1046/j.1468-2982.2001.00287.x.
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Hemicrania continua responsive to rofecoxib.
Cephalalgia. 2000 Mar;20(2):130-1. doi: 10.1046/j.1468-2982.2000.00029.x.
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Headache. 2000 Jun;40(6):498-9. doi: 10.1046/j.1526-4610.2000.00078.x.