离子流非依赖性 NMDA 受体信号转导。
Ion flux-independent NMDA receptor signaling.
机构信息
Center for Neuroscience, University of California, Davis, CA, 95618, USA.
Center for Neuroscience, University of California, Davis, CA, 95618, USA.
出版信息
Neuropharmacology. 2022 Jun 1;210:109019. doi: 10.1016/j.neuropharm.2022.109019. Epub 2022 Mar 9.
Abstract
NMDA receptors play vital roles in a broad array of essential brain functions, from synaptic transmission and plasticity to learning and memory. Historically, the fundamental roles of NMDARs were attributed to their specialized properties of ion flux. More recently, it has become clear that NMDARs also signal in an ion flux-independent manner. Here, we review these non-ionotropic NMDAR signaling mechanisms that have been reported to contribute to a broad array of neuronal functions and dysfunctions including synaptic transmission and plasticity, cell death and survival, and synaptic alterations associated with neurological disorders.
摘要
NMDA 受体在广泛的重要大脑功能中发挥着至关重要的作用，从突触传递和可塑性到学习和记忆。历史上，NMDAR 的基本作用归因于它们的离子流的特殊性质。最近，人们已经清楚地认识到，NMDAR 也以非离子流依赖的方式发出信号。在这里，我们回顾了这些非离子型 NMDA 受体信号转导机制，这些机制已被报道有助于广泛的神经元功能障碍和功能障碍，包括突触传递和可塑性、细胞死亡和存活以及与神经紊乱相关的突触改变。
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