Zheng Xiaojie, Nie Shengming, Feng Wen-Hai
State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China; Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China; Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.
State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China; Ministry of Agriculture Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China; Department of Microbiology and Immunology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.
Virol Sin. 2022 Apr;37(2):157-167. doi: 10.1016/j.virs.2022.03.006. Epub 2022 Mar 9.
African swine fever (ASF) is a highly contagious and acute hemorrhagic viral disease with a high mortality approaching 100% in domestic pigs. ASF is an endemic in countries in sub-Saharan Africa. Now, it has been spreading to many countries, especially in Asia and Europe. Due to the fact that there is no commercial vaccine available for ASF to provide sustainable prevention, the disease has spread rapidly worldwide and caused great economic losses in swine industry. The knowledge gap of ASF virus (ASFV) pathogenesis and immune evasion is the main factor to limit the development of safe and effective ASF vaccines. Here, we will summarize the molecular mechanisms of how ASFV interferes with the host innate and adaptive immune responses. An in-depth understanding of ASFV immune evasion strategies will provide us with rational design of ASF vaccines.
非洲猪瘟（ASF）是一种高度传染性的急性出血性病毒性疾病，家猪的死亡率很高，接近100%。ASF在撒哈拉以南非洲国家呈地方流行。现在，它已经传播到许多国家，尤其是亚洲和欧洲。由于目前尚无用于ASF的商业疫苗来提供可持续的预防，该疾病已在全球迅速传播，并给养猪业造成了巨大经济损失。ASF病毒（ASFV）发病机制和免疫逃逸方面的知识空白是限制安全有效的ASF疫苗开发的主要因素。在此，我们将总结ASFV如何干扰宿主固有免疫和适应性免疫反应的分子机制。深入了解ASFV免疫逃逸策略将为我们合理设计ASF疫苗提供依据。
