State Key Laboratory of Veterinary Biotechnology, National High Containment Facilities for Animal Diseases Control and Prevention, National African Swine Fever Para-reference Laboratory, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China.
Emerg Microbes Infect. 2021 Dec;10(1):2183-2193. doi: 10.1080/22221751.2021.1999779.
The Georgia-07-like genotype II African swine fever virus (ASFV) with high virulence has been prevalent in China since 2018. Here, we report that genotype I ASFVs have now also emerged in China. Two non-haemadsorbing genotype I ASFVs, HeN/ZZ-P1/21 and SD/DY-I/21, were isolated from pig farms in Henan and Shandong province, respectively. Phylogenetic analysis of the whole genome sequences suggested that both isolates share high similarity with NH/P68 and OURT88/3, two genotype I ASFVs isolated in Portugal in the last century. Animal challenge testing revealed that SD/DY-I/21 shows low virulence and efficient transmissibility in pigs, and causes mild onset of infection and chronic disease. SD/DY-I/21 was found to cause necrotic skin lesions and joint swelling. The emergence of genotype I ASFVs will present more problems and challenges for the control and prevention of African swine fever in China.
自 2018 年以来，高致病性格鲁吉亚-07 样基因型 II 非洲猪瘟病毒（ASFV）在中国流行。在这里，我们报告称，基因型 I ASFV 现在也已在中国出现。我们从河南省和山东省的养猪场中分别分离到了两株非吸附性基因型 I ASFV，即 HeN/ZZ-P1/21 和 SD/DY-I/21。全基因组序列的系统进化分析表明，这两个分离株与 NH/P68 和 OURT88/3 高度相似，后者是上世纪在葡萄牙分离的两株基因型 I ASFV。动物攻毒试验表明，SD/DY-I/21 在猪中具有低毒力和高效的传染性，可引起轻度感染和慢性疾病。SD/DY-I/21 可引起皮肤坏死性病变和关节肿胀。基因型 I ASFV 的出现将给中国的非洲猪瘟防控带来更多的问题和挑战。
