粒细胞肉瘤（“绿色瘤”）的免疫组织化学与临床病理研究

An immunohistochemical and clinicopathological study of granulocytic sarcoma ('chloroma').

作者信息

Muller S, Sangster G, Crocker J, Nar P, Burnett D, Brown G, Leyland M J

出版信息

Hematol Oncol. 1986 Apr-Jun;4(2):101-12. doi: 10.1002/hon.2900040202.

Abstract

A small series of granulocytic sarcomas (GS) or 'chloromas' has been studied by means of conventional histology and immunohistochemistry. The latter was found to be most useful in the diagnosis and characterization of these neoplasms, which are rare in Great Britain. Polytypic antisera to leukocyte elastase and cathepsin G have proved to be most useful, giving intense staining in all cases. These two markers are more specific than muramidase (lysozyme) and alpha 1-antitrypsin, since, unlike the latter two, they do not stain histiocytic cells. The results of staining with two monoclonal antisera, AGF 4.48 and AGF 4.36, are also described. In addition, the clinicopathological details of the seven cases are summarized and the literature is briefly surveyed.

摘要

我们通过传统组织学和免疫组织化学方法对一小系列粒细胞肉瘤（GS）或“绿色瘤”进行了研究。结果发现，免疫组织化学在这些肿瘤的诊断和特征描述中最为有用，而这些肿瘤在英国较为罕见。针对白细胞弹性蛋白酶和组织蛋白酶G的多克隆抗血清已被证明是最有用的，在所有病例中均呈现强烈染色。这两种标志物比溶菌酶和α1-抗胰蛋白酶更具特异性，因为与后两者不同，它们不会对组织细胞进行染色。文中还描述了两种单克隆抗血清AGF 4.48和AGF 4.36的染色结果。此外，总结了7例病例的临床病理细节，并简要回顾了相关文献。