Banik S, Grech A B, Eyden B P
Department of Histopathology, Royal Infirmary, Blackburn.
J Clin Pathol. 1989 May;42(5):483-8. doi: 10.1136/jcp.42.5.483.
Light microscopical and routine immunohistochemical studies of a cervical neoplasm in a 32 year old woman initially suggested a histiocytic lymphoma, but histochemical staining for chloroacetate esterase established the correct diagnosis. This was supported by electron microscopic findings. Eight months later the patient developed a granulocytic sarcoma in her left breast and haemotological features of acute myeloid leukaemia. Accurate initial diagnosis of granulocytic sarcoma in a non-leukaemic patient may reduce the risk of subsequent acute myeloid leukaemia if appropriate chemotherapy is begun in time.
对一名32岁女性宫颈肿瘤进行的光学显微镜和常规免疫组织化学研究最初提示为组织细胞淋巴瘤,但氯乙酸酯酶的组织化学染色确定了正确诊断。电子显微镜检查结果支持了这一诊断。八个月后,该患者左乳出现粒细胞肉瘤,并出现急性髓系白血病的血液学特征。如果能及时开始适当的化疗,对非白血病患者的粒细胞肉瘤进行准确的初始诊断可能会降低随后发生急性髓系白血病的风险。