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心力衰竭伴射血分数保留患者综合护理模式的获益:UMIPIC 项目。

Benefits of a comprehensive care model in patients with heart failure and preserved ejection fraction: The UMIPIC program.

机构信息

Servicio de Medicina Interna, Hospital Universitario Lucus Augusti, Lugo, Spain.

Servicio de Medicina Interna, Hospital Universitario Central de Asturias, Oviedo, Spain.

出版信息

Rev Clin Esp (Barc). 2022 Jun-Jul;222(6):339-347. doi: 10.1016/j.rceng.2021.11.006. Epub 2022 Mar 9.

DOI:10.1016/j.rceng.2021.11.006
PMID:35279404
Abstract

BACKGROUND

Patients with heart failure (HF) and preserved ejection fraction (HFpEF), in contrast to those with reduced ejection fraction, are older, have more comorbidities, and are not candidates for effective therapeutic measures. Therefore, they are at high risk for hospital admission and mortality. This study evaluated the benefit of a comprehensive continuous care program (UMIPIC program) in patients with HFpEF.

METHODS

We prospectively analyzed data on 2401 patients with HFpEF attended to in internal medicine departments who form part of the RICA registry. They were divided into 2 groups: one was followed-up on in the UMIPIC program (UMIPIC group, n: 1011) and another received conventional care (RICA group, n: 1390). A total of 753 patients in each group were selected by propensity score matching and admissions and mortality were assessed during 12 months of follow-up after an episode of hospitalization due to HF.

RESULTS

Compared to the RICA group, the UMIPIC group had a lower rate of HF admissions (19.2% versus 36.5%, respectively; hazard ratio [HR] = 0.56; 95% confidence interval [CI]: 0.45-0.68; p < 0.001) and mortality (12.6% versus 28%, respectively; HR = 0.40; 95% CI: 0.31-0.51; p < 0.001). There were no differences in hospitalizations for non-HF causes.

CONCLUSIONS

Implementation of the UMIPIC program, which is based on comprehensive continuous care, for patients with HFpEF and a high degree of comorbidity reduces both admissions and mortality in the first year of follow-up.

摘要

背景

与射血分数降低的心衰(HFrEF)患者相比,射血分数保留的心衰(HFpEF)患者年龄更大、合并症更多,且不是有效治疗措施的适应证。因此,他们有很高的住院和死亡风险。本研究评估了综合连续护理计划(UMIPIC 计划)对 HFpEF 患者的益处。

方法

我们前瞻性分析了参加 RICA 登记的内科就诊的 2401 例 HFpEF 患者的数据。将他们分为两组:一组接受 UMIPIC 计划(UMIPIC 组,n:1011),另一组接受常规护理(RICA 组,n:1390)。通过倾向评分匹配,每组各选择 753 例患者,评估因 HF 住院发作后 12 个月的住院和死亡率。

结果

与 RICA 组相比,UMIPIC 组 HF 再住院率较低(分别为 19.2%和 36.5%;风险比[HR] = 0.56;95%置信区间[CI]:0.45-0.68;p < 0.001)和死亡率(分别为 12.6%和 28%;HR = 0.40;95% CI:0.31-0.51;p < 0.001)。因非 HF 原因住院无差异。

结论

为 HFpEF 合并高度合并症的患者实施基于综合连续护理的 UMIPIC 计划可降低第一年随访时的再住院率和死亡率。

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