Department of Obstetrics and Gynecology, Trakya University Faculty of Medicine, Edirne, Turkey.
Tekirdag City Hospital, Tekirdag, Turkey.
Arch Gynecol Obstet. 2022 Dec;306(6):1959-1965. doi: 10.1007/s00404-022-06485-5. Epub 2022 Mar 13.
The recurrence of PPROM (Preterm Premature Rupture of Membranes) has multifactorial etiology. The aim of this study is to discuss outcome measures of subsequent PPROMs after pregnancy with PPROM before 37 weeks 'gestation.
One hundred fifty-one patients were identified with PPROM between 20 - 36 weeks of gestation between 2012 and 2017 in Trakya University Hospital. The subsequent pregnancy (n = 68) outcomes were retrospectively analyzed.
The rate of PPROMs among all deliveries was 4.7%. The recurrence rate of PPROM in the next pregnancies was 13.2%. No differences in smoking, comorbidity, latency, antibiotic use, levels of leucocytes and C-Reactive Protein were observed between women with PPROM and without PPROM in previous and subsequent pregnancies. The interpregnancy intervals in subsequent pregnancies with PPROM were significantly longer than those without PPROM (p = 0.015). The subsequent pregnancies without PPROM had longer gestational weeks of PPROM and birth according to previous pregnancies (p = 0.049; p = 0.014).
The short interpregnancy interval may be considered in the planning of pregnancies of these women who had previous PPROM.
胎膜早破（PPROM）的复发具有多因素病因。本研究旨在讨论妊娠 37 周前发生胎膜早破后再次发生胎膜早破的结局指标。
在 2012 年至 2017 年间，我们在特拉克亚大学医院确定了 151 名在 20-36 孕周发生胎膜早破的患者。回顾性分析了随后妊娠（n=68）的结局。
所有分娩中胎膜早破的发生率为 4.7%。在随后的妊娠中，胎膜早破的复发率为 13.2%。在有和没有先前和随后妊娠中胎膜早破的患者中，吸烟、合并症、潜伏期、抗生素使用、白细胞和 C 反应蛋白水平均无差异。有和没有随后发生胎膜早破的妊娠之间的妊娠间隔时间明显更长（p=0.015）。随后没有发生胎膜早破的妊娠，其胎膜早破和分娩的妊娠周数较先前妊娠更长（p=0.049；p=0.014）。
对于有过胎膜早破病史的这些妇女，在计划妊娠时可能需要考虑较短的妊娠间隔。
