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炔诺酮引起的胆汁淤积:一例报告。

Norethisterone-induced cholestasis: A case report.

作者信息

Moussaoui Safa, Abdelwahed Mehdi, Ben Chaaben Nabil, Bellalah Ahlem, Ben Fadhel Najah, Guediche Arwa, Zakhama Mejda, Tababi Ramzi, Aouam Karim, Abdelfattah Zakhama, Loghmari Hichem, Safer Leila

机构信息

Department of Gastroenterology Fattouma Bourguiba University Hospital of Monastir Tunisia.

Department of Pathology Fattouma Bourguiba University Hospital of Monastir Tunisia.

出版信息

Clin Case Rep. 2022 Mar 3;10(3):e05522. doi: 10.1002/ccr3.5522. eCollection 2022 Mar.

DOI:10.1002/ccr3.5522
PMID:35280099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8894581/
Abstract

Case presentation This case report concerns a 49-year-old woman who developed cholestasis (build-up of bile in the liver) two months and a half after initiating norethisterone, progestin-only pills, which resolved after the withdrawal of these pills.

摘要

病例报告 本病例报告涉及一名49岁女性,她在开始服用炔诺酮(仅含孕激素的避孕药)两个半月后出现胆汁淤积(胆汁在肝脏中积聚),停用这些药物后症状缓解。

相似文献

1
Norethisterone-induced cholestasis: A case report.炔诺酮引起的胆汁淤积:一例报告。
Clin Case Rep. 2022 Mar 3;10(3):e05522. doi: 10.1002/ccr3.5522. eCollection 2022 Mar.
2
A prospective randomized study comparing the clinical effects of a norethisterone and a levonorgestrel containing low dose oestrogen oral contraceptive pills.一项比较含炔诺酮和左炔诺孕酮的低剂量雌激素口服避孕药临床效果的前瞻性随机研究。
Aust N Z J Obstet Gynaecol. 1993 Feb;33(1):81-3. doi: 10.1111/j.1479-828x.1993.tb02062.x.
3
[Influence of progestins on adverse effects of oral contraceptives].[孕激素对口服避孕药不良反应的影响]
Contracept Fertil Sex (Paris). 1985 Jan;13(1 Suppl):425-30.
4
Hepatobiliary complications of oral contraceptives.口服避孕药的肝胆并发症。
J Gen Intern Med. 1992 Mar-Apr;7(2):199-209. doi: 10.1007/BF02598014.
5
Contraceptive vaginal ring-induced cholestasis in a patient with a history of intrahepatic cholestasis of pregnancy.避孕阴道环引起的妊娠肝内胆汁淤积症患者的胆汁淤积。
Clin Res Hepatol Gastroenterol. 2021 Jul;45(4):101475. doi: 10.1016/j.clinre.2020.06.002. Epub 2020 Jul 7.
6
Norethisterone-Induced Liver Injury and a Short Survey Among Gynecologists.炔诺酮所致肝损伤及妇科医生的简短调查
Cureus. 2023 Jun 12;15(6):e40300. doi: 10.7759/cureus.40300. eCollection 2023 Jun.
7
Progestin-only pills for contraception.仅含孕激素的避孕药用于避孕。
Cochrane Database Syst Rev. 2010 Jan 20(1):CD007541. doi: 10.1002/14651858.CD007541.pub2.
8
Progestin-only pills for contraception.仅含孕激素的避孕药用于避孕。
Cochrane Database Syst Rev. 2013 Nov 13;2013(11):CD007541. doi: 10.1002/14651858.CD007541.pub3.
9
A quantitative study of the pregnancy zone protein in sera of woman taking oral contraceptives.口服避孕药女性血清中妊娠区带蛋白的定量研究。
Am J Obstet Gynecol. 1976 Feb 1;124(3):289-92. doi: 10.1016/0002-9378(76)90159-9.
10
Long-acting contraceptive agents: bile acid esters of norethisterone.长效避孕药:炔诺酮胆汁酸酯。
Steroids. 1983 Mar;41(3):327-31. doi: 10.1016/0039-128x(83)90103-4.

本文引用的文献

1
Rare case of obstetric cholestasis presenting in the first trimester following in vitro fertilisation.罕见的体外受精后早孕合并妊娠肝内胆汁淤积症病例。
BMJ Case Rep. 2021 Jul 7;14(7):e244254. doi: 10.1136/bcr-2021-244254.
2
Molecular overview of progressive familial intrahepatic cholestasis.进行性家族性肝内胆汁淤积症的分子概述
World J Gastroenterol. 2020 Dec 21;26(47):7470-7484. doi: 10.3748/wjg.v26.i47.7470.
3
Intrahepatic Cholestasis of Pregnancy.妊娠肝内胆汁淤积症。
Clin Obstet Gynecol. 2020 Mar;63(1):134-151. doi: 10.1097/GRF.0000000000000495.
4
Mechanisms and in vitro models of drug-induced cholestasis.药物性胆汁淤积的机制和体外模型。
Arch Toxicol. 2019 May;93(5):1169-1186. doi: 10.1007/s00204-019-02437-2. Epub 2019 Apr 10.
5
Drug-induced cholestasis.药物性胆汁淤积
Hepatol Commun. 2017 Sep 11;1(8):726-735. doi: 10.1002/hep4.1088. eCollection 2017 Oct.
6
Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype.妊娠肝内胆汁淤积症中硫酸孕烯醇酮代谢物的水平抑制法尼醇 X 受体,导致胆汁淤积表型。
Hepatology. 2013 Feb;57(2):716-26. doi: 10.1002/hep.26055. Epub 2013 Jan 8.
7
Inhibition of Na+-taurocholate Co-transporting polypeptide-mediated bile acid transport by cholestatic sulfated progesterone metabolites.胆汁酸转运蛋白介导的胆汁酸转运被胆淤积性硫酸化孕烯醇酮代谢物所抑制。
J Biol Chem. 2010 May 28;285(22):16504-12. doi: 10.1074/jbc.M109.072140. Epub 2010 Feb 20.
8
Human drug hepatotoxicity: a contemporary clinical perspective.人类药物肝毒性:当代临床视角
Expert Opin Drug Metab Toxicol. 2009 May;5(5):463-73. doi: 10.1517/17425250902927386.
9
Intrahepatic cholestasis of pregnancy: when should you look further?妊娠肝内胆汁淤积症:何时应进一步检查?
World J Gastroenterol. 2009 Mar 7;15(9):1126-9. doi: 10.3748/wjg.15.1126.
10
Immune-mediated drug-induced liver disease.免疫介导的药物性肝病
Clin Liver Dis. 2002 Aug;6(3):755-74. doi: 10.1016/s1089-3261(02)00025-9.