Ridgway Rachel, Neary Joseph, Turner Andrea, Barrett David C, Gillespie Amy
Institute of Infection, Veterinary and Ecological Sciences, Livestock and One Health, University of Liverpool, Neston, United Kingdom.
School of Veterinary Science, University of Bristol, Bristol, United Kingdom.
Front Vet Sci. 2022 Feb 24;9:745632. doi: 10.3389/fvets.2022.745632. eCollection 2022.
Oxytetracycline is commonly applied as a topical agent to burn lesions post cautery disbudding of calves. Judicial use of antibiotics dictates that they should only be used where necessary to reduce the development of resistance in target bacteria. The objective of this study, therefore, was to evaluate the efficacy of topical oxytetracycline spray on wound healing post cautery disbudding of dairy calves over a 6-week period. Dairy calves were disbudded by veterinarians, technicians, or veterinary surgeons, using a standard cautery disbudding protocol. Oxytetracycline spray was randomly applied to the right or left horn bud of each animal (OXY), while the other horn bud received no antibiotic spray (NA). The outcomes measured were wound diameter (WD) and lesion score (LS), either normal healing (NH) or abnormal healing (AH). These assessments were conducted every 14 days following disbudding, until 42 days. A total of 360 animals completed the study. There was a difference in wound diameter and lesion score on day 14 post disbudding between the two groups. Cautery lesions sprayed with oxytetracycline (OXY) were 0.5 ± 0.15 mm smaller than NA lesions ( = 0.001), and there were fewer abnormal healing lesions for OXY compared to the NA (2.5 vs. 11%, respectively; ≤ 0.001). There were no differences at day 28 and day 42 post disbudding, and on day 42, 34% of wounds had healed in both groups. In summary, the authors were unable to demonstrate a difference in healing between the groups using the described methods.
土霉素通常作为局部用药应用于犊牛灼烙去角术后的烧伤创面。合理使用抗生素要求仅在必要时使用，以减少目标细菌耐药性的产生。因此，本研究的目的是评估局部使用土霉素喷雾剂对奶牛犊牛灼烙去角术后6周内伤口愈合的效果。奶牛犊牛由兽医、技术人员或兽医外科医生按照标准的灼烙去角方案进行去角。将土霉素喷雾剂随机应用于每只动物的右角芽或左角芽（OXY），而另一个角芽不喷洒抗生素（NA）。测量的结果是伤口直径（WD）和损伤评分（LS），分为正常愈合（NH）或异常愈合（AH）。去角后每14天进行一次这些评估，直至42天。共有360只动物完成了研究。两组在去角后第14天的伤口直径和损伤评分存在差异。喷洒土霉素（OXY）的灼烙损伤比未喷洒组（NA）小0.5±0.15毫米（P = 0.001），与NA组相比，OXY组的异常愈合损伤更少（分别为2.5%和11%；P≤0.001）。去角后第28天和第42天两组无差异，在第42天，两组中34%的伤口已愈合。总之，作者未能证明使用所述方法的两组之间在愈合方面存在差异。
