Siebner Thomas Hartwig, Fuglsang Stefan, Madelung Christopher Fugl, Løkkegaard Annemette, Bendtsen Flemming, Hove Jens Dahlgaard, Damgaard Morten, Madsen Jan Lysgård, Siebner Hartwig Roman
Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark.
Department of Cardiology, Copenhagen University Hospital-Amager and Hvidovre, Copenhagen, Denmark.
Front Neurol. 2022 Feb 24;13:828069. doi: 10.3389/fneur.2022.828069. eCollection 2022.
We have recently used phase-contrast magnetic resonance imaging (PC-MRI) to demonstrate an attenuated postprandial blood flow response in the superior mesenteric artery (SMA) in 23 medicated patients with Parkinson's disease (PD) compared to 23 age- and sex-matched healthy controls.
To investigate in a sub-sample of the original cohort whether the observed blood flow response in SMA after oral food intake is related to a delay in gastric emptying.
We studied 15 patients with PD in an "ON-medication" state with a mean disease duration of 3.9 ± 2.2 years and 15 healthy age- and sex-matched individuals. Participants underwent dynamic gastric scintigraphy 0, 30, 60, 120, 180 and 240 minutes after the intake of a standardized radiolabeled test meal. Gastric emptying was compared between groups. 14 of the 15 PD patients and 12 of the 15 healthy control subjects had previously undergone serial postprandial PC-MRI measurements. In these individuals, we tested for a relationship between gastric emptying and postprandial blood flow response in the SMA.
The dynamics of gastric emptying did not differ between groups ( = 0.68). There was substantial inter-subject variability of gastric emptying in PD patients and healthy participants. Only a single PD patient had delayed gastric emptying. In those participants who had undergone PC-MRI, postprandial increase in SMA blood flow was attenuated in PD compared to healthy controls as reported previously ( = 0.006). Gastric emptying did not correlate with the timing and amplitude of postprandial blood flow increase in SMA.
Our preliminary results, obtained in a small group of early-stage PD patients who continued their usual dopamine replacement therapy, suggest that variations in gastric emptying after solid meal intake is within the normal range in the majority of cases. There is also no evidence for a tight relationship between the attenuated postprandial blood flow response in the SMA and normal variations in gastric emptying.
我们最近利用相位对比磁共振成像（PC-MRI）发现，与23名年龄和性别匹配的健康对照者相比，23名接受药物治疗的帕金森病（PD）患者餐后肠系膜上动脉（SMA）的血流反应减弱。
在原始队列的一个子样本中研究口服食物后SMA中观察到的血流反应是否与胃排空延迟有关。
我们研究了15名处于“服药”状态的PD患者，平均病程为3.9±2.2年，以及15名年龄和性别匹配的健康个体。参与者在摄入标准化放射性标记测试餐后0、30、60、120、180和240分钟接受动态胃闪烁扫描。比较两组之间的胃排空情况。15名PD患者中的14名和15名健康对照者中的12名此前已接受系列餐后PC-MRI测量。在这些个体中，我们测试了胃排空与SMA餐后血流反应之间的关系。
两组之间胃排空的动态变化没有差异（P = 0.68）。PD患者和健康参与者的胃排空存在很大的个体间差异。只有一名PD患者胃排空延迟。在那些接受PC-MRI的参与者中，与健康对照者相比，PD患者餐后SMA血流增加减弱，如先前报道（P = 0.006）。胃排空与SMA餐后血流增加的时间和幅度无关。
我们在一小群继续常规多巴胺替代治疗的早期PD患者中获得的初步结果表明，大多数情况下，固体食物摄入后胃排空的变化在正常范围内。也没有证据表明SMA餐后血流反应减弱与胃排空的正常变化之间存在密切关系。
