Department of Medical Oncology, Cancer Center and Laboratory of Molecular Targeted Therapy in Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, China.
Int J Biol Sci. 2022 Feb 7;18(4):1695-1705. doi: 10.7150/ijbs.64982. eCollection 2022.
Ferroptosis, a new form of programmed necrosis characterized by iron-dependent lethal accumulation of lipid hydroperoxides, is associated with many human diseases. Targeting amino acid (AA) availability can selectively suppress tumor growth and has been a promising therapeutic strategy for cancer therapy. Compelling studies have indicated that AA metabolism is also involved in ferroptosis, closely regulating its initiation and execution. This manuscript systematically summarizes the latest advances of AA metabolism in regulating ferroptosis and discusses the potential combination of therapeutic strategies that simultaneously target AA metabolism and ferroptosis in cancer to eliminate tumors or limit their invasiveness.
铁死亡是一种新的程序性细胞坏死形式，其特征是铁依赖性脂质过氧化物的致死性积累，与许多人类疾病有关。靶向氨基酸（AA）可用性可以选择性地抑制肿瘤生长，已成为癌症治疗的一种有前途的治疗策略。令人信服的研究表明，AA 代谢也参与铁死亡，密切调节其起始和执行。本文系统总结了 AA 代谢在调节铁死亡方面的最新进展，并讨论了同时针对癌症中的 AA 代谢和铁死亡的治疗策略的潜在组合，以消除肿瘤或限制其侵袭性。
