Lin Naiyu, Li Xiaoli, Lang Yuejiao, Han Jiande
Department of Dermatology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Front Med (Lausanne). 2022 Feb 24;9:844223. doi: 10.3389/fmed.2022.844223. eCollection 2022.
Pemphigus is an autoimmune disease that occurs mainly in elderly individuals. Young patients with pemphigus are rare, and the risk factors are unclear. The thymus is associated with a variety of autoimmune diseases, and there have been reports of pemphigus complicated with thymic diseases. Here, we report three cases of young patients with pemphigus that were associated with thymic anomalies. We suggest that thymic anomalies may be a risk factor for the early onset of pemphigus and may be associated with increased severity of the disease. Interventions for thymic diseases have certain benefits for improving the effect of treatments and prognosis of these patients.
天疱疮是一种主要发生于老年人的自身免疫性疾病。年轻的天疱疮患者较为罕见,且危险因素尚不清楚。胸腺与多种自身免疫性疾病相关,已有天疱疮合并胸腺疾病的报道。在此,我们报告3例与胸腺异常相关的年轻天疱疮患者。我们认为胸腺异常可能是天疱疮早发的一个危险因素,且可能与疾病严重程度增加有关。针对胸腺疾病的干预措施对改善这些患者的治疗效果及预后有一定益处。