Younus J, Ahmed A R
Department of Pathology, Boston University School of Medicine, MA.
J Am Acad Dermatol. 1990 Sep;23(3 Pt 1):498-502. doi: 10.1016/0190-9622(90)70249-h.
A statistically increased incidence of malignancy has been observed in patients with pemphigus. A review of the literature reveals 42 cases of nonthymic malignancies and 18 cases of thymic malignancies. A significant predominance of men, with mean age at onset of 50 years, was observed. Pemphigus vulgaris is more common in patients with nonthymic neoplasms, whereas pemphigus foliaceus or pemphigus erythematosus and pemphigus vulgaris are equally common in patients with thymic neoplasms. Lymphoreticular malignancies, especially Kaposi's sarcoma, are most frequently observed. The majority of patients with nonthymic neoplasms have pemphigus before the detection of the malignancy and have a favorable 5-year survival rate after tumor resection. The majority of the patients with thymic neoplasms have a thymoma before the development of pemphigus. In some patients pemphigus develops after thymectomy and myasthenia gravis is often associated. Overall, 37 of the 60 patients, or 61%, had a neoplasm of the immune system.
在天疱疮患者中观察到恶性肿瘤的发生率在统计学上有所增加。文献回顾显示有42例非胸腺恶性肿瘤和18例胸腺恶性肿瘤。观察到男性占显著优势，发病的平均年龄为50岁。寻常型天疱疮在非胸腺肿瘤患者中更为常见，而落叶型天疱疮、红斑型天疱疮和寻常型天疱疮在胸腺肿瘤患者中同样常见。淋巴网状恶性肿瘤，尤其是卡波西肉瘤，最为常见。大多数非胸腺肿瘤患者在检测到恶性肿瘤之前就患有天疱疮，肿瘤切除后5年生存率良好。大多数胸腺肿瘤患者在天疱疮发生之前患有胸腺瘤。在一些患者中，天疱疮在胸腺切除术后发生，且常伴有重症肌无力。总体而言，60例患者中有37例（即61%）患有免疫系统肿瘤。
