Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin, China.
Department of Emergency Medicine, Rizhao People's Hospital of Shandong Province, Rizhao, China.
Front Immunol. 2022 Feb 25;13:829210. doi: 10.3389/fimmu.2022.829210. eCollection 2022.
Sepsis is a syndrome characterized by life-threatening organ dysfunction caused by the dysregulated host response to an infection. Sepsis, especially septic shock and multiple organ dysfunction is a medical emergency associated with high morbidity, high mortality, and prolonged after-effects. Over the past 20 years, regulatory T cells (Tregs) have been a key topic of focus in all stages of sepsis research. Tregs play a controversial role in sepsis based on their heterogeneous characteristics, complex organ/tissue-specific patterns in the host, the multi-dimensional heterogeneous syndrome of sepsis, the different types of pathogenic microbiology, and even different types of laboratory research models and clinical research methods. In the context of sepsis, Tregs may be considered both angels and demons. We propose that the symptoms and signs of sepsis can be attenuated by regulating Tregs. This review summarizes the controversial roles and Treg checkpoints in sepsis.
脓毒症是一种综合征，其特征是宿主对感染的失调反应导致危及生命的器官功能障碍。脓毒症，特别是感染性休克和多器官功能障碍，是一种与高发病率、高死亡率和长期后遗症相关的医疗急症。在过去的 20 年中，调节性 T 细胞（Tregs）一直是脓毒症研究各个阶段的一个关键主题。基于其异质性特征、宿主中复杂的器官/组织特异性模式、脓毒症的多维异质性综合征、不同类型的致病微生物学，甚至不同类型的实验室研究模型和临床研究方法，Tregs 在脓毒症中的作用存在争议。在脓毒症的背景下，Tregs 可能被认为是天使和魔鬼的结合体。我们提出，通过调节 Tregs 可以减轻脓毒症的症状和体征。本综述总结了 Tregs 在脓毒症中的争议作用和 Treg 检查点。
