Department of Anesthesiology, Wake Forest School of Medicine, Wake Forest Baptist Medical Center, 1, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Department of Anesthesiology, Section on Critical Care Medicine, Wake Forest School of Medicine, Wake Forest Baptist Medical Center, 1, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Med Clin North Am. 2020 Jul;104(4):573-585. doi: 10.1016/j.mcna.2020.02.011. Epub 2020 May 12.
Sepsis and septic shock are major causes of mortality among hospitalized patients. The sepsis state is due to dysregulated host response to infection, leading to inflammatory damage to nearly every organ system. Early recognition of sepsis and appropriate treatment with antibiotics, fluids, and vasopressors is essential to reducing organ system injury and mortality. This review summarizes the current understanding of the epidemiology, pathophysiology, diagnosis, and treatment of sepsis and septic shock.
脓毒症和感染性休克是住院患者死亡的主要原因。脓毒症状态是由于宿主对感染的反应失调，导致几乎所有器官系统发生炎症性损伤。早期识别脓毒症并使用抗生素、液体和血管加压药进行适当治疗对于减少器官系统损伤和死亡率至关重要。本文综述了脓毒症和感染性休克的流行病学、病理生理学、诊断和治疗的最新认识。
