School of Medicine, Zhejiang University, Hangzhou, China.
Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Immunol. 2022 Feb 24;13:844001. doi: 10.3389/fimmu.2022.844001. eCollection 2022.
Mesenchymal stem cells (MSCs) were reported to have strong immunomodulatory ability, and inhibit the proliferation of T cells and their immune response through cell-to-cell interactions and the generation of cytokines. With high differentiation potential and self-renewal ability, MSCs are considered to function in alleviating inflammatory responses, promoting tissue regeneration and inhibiting tissue fibrosis formation. As the most common malignancies, gastrointestinal (GI) cancers have high incidence and mortality. The accurate diagnosis, exact prognosis and treatment of GI cancers have always been a hot topic. Therefore, the potential applications of MSCs in terms of GI cancers are receiving more and more attention. Recently, there is increasing evidence that MSCs may serve as a key point in the growth, metastasis, inhibition, treatment and prognosis of GI cancers. In this review, we summarized the roles of MSCs in GI cancers, mainly focusing on esophageal cancer (EC), gastric cancer (GC), liver cancer (LC), colorectal cancer (CRC) and pancreatic cancer. Besides, we proposed MSCs as potential targets and treatment strategies for the effective treatment of GI cancers, which may provide better guidance for the clinical treatment of GI cancers.
间充质干细胞（MSCs）被报道具有强大的免疫调节能力，通过细胞间相互作用和细胞因子的产生，抑制 T 细胞的增殖及其免疫反应。MSCs 具有高分化潜能和自我更新能力，被认为在缓解炎症反应、促进组织再生和抑制组织纤维化形成方面发挥作用。作为最常见的恶性肿瘤，胃肠道（GI）癌症具有较高的发病率和死亡率。GI 癌症的准确诊断、确切预后和治疗一直是热点话题。因此，MSCs 在 GI 癌症方面的潜在应用越来越受到关注。最近越来越多的证据表明，MSCs 可能是 GI 癌症生长、转移、抑制、治疗和预后的关键点。在本综述中，我们总结了 MSCs 在 GI 癌症中的作用，主要集中在食管癌（EC）、胃癌（GC）、肝癌（LC）、结直肠癌（CRC）和胰腺癌。此外，我们提出 MSCs 作为 GI 癌症有效治疗的潜在靶点和治疗策略，这可能为 GI 癌症的临床治疗提供更好的指导。
