Vibhute Nupura Aniket, Jagtap Sunil Vitthalrao, Patil Sujata Vijaysinh
Department of Oral Pathology and Microbiology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed to be University, Karad, Maharashtra, India.
Department of Pathology, Krishna Institute of Medical Sciences Deemed to be University, Karad, Maharashtra, India.
J Oral Maxillofac Pathol. 2021 Sep-Dec;25(3):548-549. doi: 10.4103/jomfp.JOMFP_315_20. Epub 2022 Jan 11.
Early oral cancer diagnosis is an important factor in reducing cancer-associated mortality and morbidity. Traditional oral cancer screening by Conventional Oral Examination (COE) is limited. A new approach in this regard is the use of "optical biopsy systems" like VELscope.
Hence, this study aimed to determine the diagnostic value of VELscope, an autofluorescence-based handheld device in detection of dysplasia and oral squamous cell carcinoma (OSCC) in general oral potentially malignant disorder.
A prospective, cross-sectional study was conducted at a tertiary hospital in western Maharashtra, India.
Thirty patients with presence of clinically suspicious oral lesions were included, and for each lesion, both the COE and Autofluorescence Examination by VELscope were carried out at the same appointment by different experts. All lesions were biopsied and histopathological findings were documented and analyzed.
Sensitivity, specificity, positive predictive value and negative predictive value were estimated to determine the accuracy of VELscope examination analysis outcome.
The study included a total of 30 subjects including 19 (63.33%) males and 11 (26.66%) females. Autofluorescence examination by VELscope (AFV) revealed Autofluorescence Loss in 24 (80%) patients, while 6 (20%) patients showed Autofluorescence Retained. Comparison between the "high-risk lesions" (moderate/severe dysplasia and OSCC) and "low-risk lesions" (no/mild dysplasia) showed a 90.47% sensitivity but only 44.44% specificity.
The findings of our study indicate that although AFV cannot be a substitute for COE, it can be used as a potential complementary diagnostic aid in surveillance of the high-risk patient population.
早期口腔癌诊断是降低癌症相关死亡率和发病率的重要因素。传统的通过常规口腔检查（COE）进行的口腔癌筛查存在局限性。在这方面的一种新方法是使用像VELscope这样的“光学活检系统”。
因此，本研究旨在确定VELscope（一种基于自体荧光的手持式设备）在一般口腔潜在恶性疾病中检测发育异常和口腔鳞状细胞癌（OSCC）的诊断价值。
在印度马哈拉施特拉邦西部的一家三级医院进行了一项前瞻性横断面研究。
纳入30例临床上有可疑口腔病变的患者，对于每个病变，由不同专家在同一预约时间进行COE和VELscope自体荧光检查。对所有病变进行活检，并记录和分析组织病理学结果。
估计敏感性、特异性、阳性预测值和阴性预测值，以确定VELscope检查分析结果的准确性。
该研究共纳入30名受试者，其中男性19名（63.33%），女性11名（26.66%）。VELscope自体荧光检查（AFV）显示24例（80%）患者出现自体荧光丧失，而6例（20%）患者显示自体荧光保留。“高危病变”（中度/重度发育异常和OSCC）与“低危病变”（无/轻度发育异常）之间的比较显示敏感性为90.47%，但特异性仅为44.44%。
我们的研究结果表明，虽然AFV不能替代COE，但它可作为高危患者群体监测中的一种潜在辅助诊断手段。
