Mahapatra Niva, Uma Rao Krishna Devi, Ranganathan Kannan, Joshua Elizabeth, Thavarajah Rooban
Department of Oral and Maxillofacial Pathology, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India.
Department Oral and Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai, Tamil Nadu, India.
J Oral Maxillofac Pathol. 2021 Sep-Dec;25(3):552. doi: 10.4103/jomfp.jomfp_13_21. Epub 2022 Jan 11.
Oral cancer is the 8 most common cancer in the world. An important feature of carcinogenesis is angiogenesis. Endoglin is a powerful marker of neovascularization in solid malignancies. This study was done to ascertain its role as an indicator of metastasis and prognosis.
This study aimed to evaluate and compare the expression of endoglin (CD105) in metastatic primary tumor, lymph node of the metastasized tumor, nonmetastatic primary tumor and in normal buccal mucosa immunohistochemically.
The total sample size comprised 45 formalin-fixed paraffin-embedded tissue blocks, = 10 metastasized primary tumor, = 10 lymph nodes of metastasized primary tumor, = 20 nonmetastasized oral squamous cell carcinoma and = 5 normal buccal mucosa were studied.
Immunohistochemistry for endoglin was performed and microvessel density (MVD) was determined by hot spot method. Microvessel density was compared between the groups.
Statistical analysis was used using one-way ANOVA. < 0.05 was statistically significant.
Endoglin expression in metastatic cases (0.68 + 0.10) was higher than nonmetastatic cases (0.45 + 0.20) and the difference was statistically significant ( = 0.002).
This study shows that presence of endoglin determines the metastatic potential of the tumor and its prognosis, thus, could be considered as a potential target of therapy.
口腔癌是全球第八大常见癌症。肿瘤发生的一个重要特征是血管生成。内皮糖蛋白是实体恶性肿瘤新生血管形成的有力标志物。本研究旨在确定其作为转移和预后指标的作用。
本研究旨在通过免疫组织化学方法评估和比较内皮糖蛋白（CD105）在转移性原发性肿瘤、转移瘤淋巴结、非转移性原发性肿瘤及正常颊黏膜中的表达。
总样本量包括45个福尔马林固定石蜡包埋组织块，其中10个为转移性原发性肿瘤，10个为转移性原发性肿瘤的淋巴结，20个为非转移性口腔鳞状细胞癌，5个为正常颊黏膜。
进行内皮糖蛋白免疫组织化学检测，并采用热点法测定微血管密度（MVD）。比较各组间的微血管密度。
采用单因素方差分析进行统计分析。P<0.05具有统计学意义。
转移性病例中内皮糖蛋白表达（0.68±0.10）高于非转移性病例（0.45±0.20），差异具有统计学意义（P=0.002）。
本研究表明内皮糖蛋白的存在决定了肿瘤的转移潜能及其预后，因此可被视为潜在的治疗靶点。
