Urbonas Vaidotas, Varnas Dominykas, Mociskiene Kristina, Kvedariene Violeta, Rudzeviciene Odilija
Vilnius University Faculty of Medicine Clinic of Children's Diseases, Vilnius, Lithuania.
Front Pediatr. 2022 Feb 24;10:830611. doi: 10.3389/fped.2022.830611. eCollection 2022.
DRESS syndrome is defined as drug-induced hypersensitivity syndrome with rash, eosinophilia, and systemic symptoms. This syndrome is mostly associated with anticonvulsants, antibacterial and anti-inflammatory drugs. DRESS syndrome is a rare disease and is more frequently seen in adults. We present the first case report of DRESS syndrome in an 8-year-old girl, after 3 months of treatment with isoniazid and rifampicin. After discontinuation of drugs and a short course of prednisolone the girl recovered. After 5 years of follow-up, she is healthy and has no complaints but patch tests with isoniazid and rifampicin remain positive. The reported case emphasizes the importance of thorough medical history and including drug reactions in differential diagnosis.
药物超敏反应伴嗜酸性粒细胞增多和全身症状综合征（DRESS综合征）的定义为药物诱导的超敏反应综合征，伴有皮疹、嗜酸性粒细胞增多和全身症状。该综合征大多与抗惊厥药、抗菌药和抗炎药有关。DRESS综合征是一种罕见疾病，在成年人中更为常见。我们报告了首例8岁女童在接受异烟肼和利福平治疗3个月后发生DRESS综合征的病例。停药并短期使用泼尼松龙治疗后，该女童康复。经过5年的随访，她身体健康，无任何不适，但异烟肼和利福平的斑贴试验仍为阳性。该病例报告强调了详细病史以及在鉴别诊断中纳入药物反应的重要性。
