Irga Ninela, Kosiak Wojciech, Jaworski Radoslaw, Zielinski Jacek, Adamkiewicz-Drozynska Elzbieta
Department of Paediatrics, Haematology, Oncology and Endocrinology, Medical University of Gdansk, Gdansk, Poland.
Pediatr Emerg Care. 2013 Apr;29(4):504-7. doi: 10.1097/PEC.0b013e31828a3854.
Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a severe drug-induced hypersensitivity syndrome and may be observed after administration of many drugs. Clinical symptoms usually occur 2 to 8 weeks after drug introduction. Because DRESS syndrome is potentially life threatening, it is especially important to diagnose it early. Withdrawal of the drug which induced symptoms is the most important therapeutic option. DRESS syndrome appears mostly in adults. There are relatively few articles on the DRESS syndrome in children. The article presents a case of a 4-year-old girl with a life-threatening clinical course of DRESS syndrome with massive pulmonary involvement. The knowledge of DRESS syndrome clinical symptoms is essential for doctors of various specialties. It is especially important that general practitioners, pediatricians, and pediatric neurologists should be able to take this life-threatening syndrome into consideration for differential diagnosis.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征是一种严重的药物性超敏综合征，在使用多种药物后均可能出现。临床症状通常在用药后2至8周出现。由于DRESS综合征可能危及生命，早期诊断尤为重要。停用引起症状的药物是最重要的治疗选择。DRESS综合征多见于成年人。关于儿童DRESS综合征的文章相对较少。本文报道了一例4岁女童，患有危及生命的DRESS综合征临床病程，伴有大量肺部受累。了解DRESS综合征的临床症状对各专科医生至关重要。全科医生、儿科医生和儿科神经科医生尤其应能够在鉴别诊断时考虑到这种危及生命的综合征。
