Autret-Leca E, Norbert K, Bensouda-Grimaldi L, Jonville-Béra A-P, Saliba E, Bentata J, Barthez-Carpentier M-A
Service de pharmacologie, centre régional de pharmacovigilance et d'information sur le médicament, hôpital Bretonneau, CHRU de Tours, Tours cedex 09, France.
Arch Pediatr. 2007 Dec;14(12):1439-41. doi: 10.1016/j.arcped.2007.07.016. Epub 2007 Nov 7.
The DRESS syndrome (Rash with Eosinophilia and Systemic Symptoms) is a drug hypersensitivity reaction poorly known by paediatricians. It occurs within 1 to 8 weeks of treatment. Clinical features associate in variable patterns, fever, rash, lymphadenopathies, arthritis and potentially life-threatening damage (hepatitis, nephritis, pneumonitis), hyperleucocytosis and eosinophilia. This condition must be early recognized in order to immediately stop suspect drugs. A 6.5 year old girl had a febrile rash, hyperleucocytosis, lymph nodes and cytolitic hepatitis probably due to phenobarbital. Diagnosis of DRESS syndrome was performed only 13 days after the beginning of the eruption. Evolution was favorable but characterized by the recurrence of the febrile eruption with pleuritis. DRESS syndrome is a well described disease that occurs during treatment with a number drugs, particularly anti-epileptic drugs. Steroid therapy and immunoglobulins are proposed for treatment but have not been evaluated.
药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS综合征）是一种儿科医生了解较少的药物过敏反应。它发生在治疗的1至8周内。临床特征以多种不同模式出现，包括发热、皮疹、淋巴结病、关节炎以及潜在的危及生命的损害（肝炎、肾炎、肺炎）、白细胞增多和嗜酸性粒细胞增多。必须尽早识别这种情况，以便立即停用可疑药物。一名6.5岁女孩出现发热性皮疹、白细胞增多、淋巴结肿大和溶细胞性肝炎，可能是由苯巴比妥引起的。皮疹出现13天后才诊断出DRESS综合征。病情演变良好，但以伴有胸膜炎的发热性皮疹复发为特征。DRESS综合征是一种在用多种药物治疗期间发生的已被充分描述的疾病，尤其是抗癫痫药物。有人提议用类固醇疗法和免疫球蛋白进行治疗，但尚未进行评估。
