Dai Shiyi, Yang Kaiying, Qiu Tong, Zhou Jiangyuan, Zhang Xuepeng, Chen Siyuan, Li Lizhi, Ji Yi
Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China.
Pediatric Intensive Care Unit, Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.
Front Pediatr. 2022 Feb 24;10:720611. doi: 10.3389/fped.2022.720611. eCollection 2022.
Kaposiform hemangioendothelioma (KHE) is a rare, aggressive and borderline vascular tumor mainly occurring in infants and children. The aim of this study was to determine the health-related quality of life (HRQOL) in children with KHE.
A total of 91 children with KHE participated in this cross-sectional study. The HRQOL was assessed by the age-specific Pediatric Quality of Life Inventory Version 4.0 (PedsQL™ 4.0) Infant Scales, Family Information Form (FIF), Family Impact Module (FIM) and Generic Core Scales (GCS). For comparison, demographically matched healthy children were recruited as a control group. The main outcome measure of HRQOL was analyzed in the two groups. We determined related factors that influenced the HRQOL in children with KHE and their parents by using a stepwise multiple regression analysis.
The study found that the scores of each item in the family impact module (FIM) were lower than 75, which suggesting that KHE can make the parents of patients in a state of poor quality of life. The scores of physiological and psychosocial domains in all age groups of patients with KHE were lower than those of normal children ( < 0.01). Activity dysfunction is the factor influencing the physiological function score of all-age patients. KMP is the factor influencing the psychosocial function score of all-age patients.
The findings presented here suggest that patients with KHE have a poor HRQOL. KMP and activity dysfunction are risk factors for poor HRQOL in patients with KHE. However, lesion size, lesion location and education level of the mother and father were not related to the HRQOL.
卡波西样血管内皮瘤（KHE）是一种罕见的、侵袭性的交界性血管肿瘤，主要发生于婴幼儿和儿童。本研究旨在确定KHE患儿的健康相关生活质量（HRQOL）。
共有91例KHE患儿参与了这项横断面研究。采用特定年龄的儿童生活质量量表第4版（PedsQL™ 4.0）婴儿量表、家庭信息表（FIF）、家庭影响模块（FIM）和通用核心量表（GCS）对HRQOL进行评估。为作比较，招募了人口统计学特征匹配的健康儿童作为对照组。对两组的HRQOL主要结局指标进行分析。通过逐步多元回归分析确定影响KHE患儿及其父母HRQOL的相关因素。
研究发现，家庭影响模块（FIM）中各项目得分均低于75分，这表明KHE可使患儿父母处于生活质量较差的状态。KHE患儿各年龄组的生理和心理社会领域得分均低于正常儿童（P<0.01）。活动功能障碍是影响各年龄段患者生理功能得分的因素。KMP是影响各年龄段患者心理社会功能得分的因素。
本研究结果表明，KHE患者的HRQOL较差。KMP和活动功能障碍是KHE患者HRQOL较差的危险因素。然而，病变大小、病变部位以及父母的教育程度与HRQOL无关。
