Wang Chuan, Li Yanan, Xiang Bo, Xiong Fei, Li Kai, Yang Kaiying, Chen Siyuan, Ji Yi
Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, #37 Guo-Xue-Xiang, Chengdu, Sichuan Province, 610041, China.
Department of Child Health, West China Second University Hospital, Sichuan University, Sichuan Province, Chengdu, China.
Health Qual Life Outcomes. 2017 Nov 16;15(1):221. doi: 10.1186/s12955-017-0772-z.
Infantile hemangioma (IH) is the most common vascular tumor in children. It is controversial whether IHs has effects on the quality of life (QOL) in patients of whom IH poses no threat or potential for complication. Thus, we conducted this study to evaluate the q QOL in patients with IH and find the predictors of poor QOL.
The PedsQL 4.0 Genetic Core Scales and the PedsQL family information form were administered to parents of children with IH and healthy children both younger than 2-year-old. The quality-of-life instrument for IH (IH-QOL) and the PedsQL 4.0 family impact module were administered to parents of children with IH. We compared the PedsQL 4.0 Genetic Core Scales (GCIS) scores of the two groups. Multiple step-wise regression analysis was used to determine factors that influenced QOL in children with IH and their parents.
Except for physical symptom, we found no significant difference in GCIS between patient group and healthy group (P = 0.409). The internal reliability of IH-QOL was excellent with the Cronbach's alpha coefficient for summary scores being 0.76. Multiple step-wise regression analysis showed that the predictors of poor IH-QOL total scores were hemangioma size, location, and mother's education level. The predictors of poor FIM total scores were hemangioma location and father's education level. The predictors of poor GCIS total scores were children's age, hemangioma location and father's education level.
The findings support the feasibility and reliability of the Chinese version of IH-QOL to evaluate the QOL in children with IH and their parents. Hemangioma size, location and education level of mother are important impact factors for QOL in children with IH and their parents.
婴儿血管瘤（IH）是儿童最常见的血管肿瘤。对于IH对无威胁或无并发症风险患者生活质量（QOL）是否有影响存在争议。因此，我们开展本研究以评估IH患者的生活质量并找出生活质量差的预测因素。
对年龄小于2岁的IH患儿及健康儿童的父母使用儿童生活质量量表4.0遗传核心量表（PedsQL 4.0 Genetic Core Scales）和儿童生活质量量表家庭信息表。对IH患儿的父母使用IH生活质量量表（IH-QOL）和儿童生活质量量表4.0家庭影响模块。我们比较了两组的儿童生活质量量表4.0遗传核心量表（GCIS）得分。采用多元逐步回归分析确定影响IH患儿及其父母生活质量的因素。
除身体症状外，我们发现患者组和健康组的GCIS无显著差异（P = 0.409）。IH-QOL的内部信度极佳，总分的Cronbach's α系数为0.76。多元逐步回归分析显示，IH-QOL总分低的预测因素为血管瘤大小、位置和母亲的教育水平。家庭影响模块（FIM）总分低的预测因素为血管瘤位置和父亲的教育水平。GCIS总分低的预测因素为儿童年龄、血管瘤位置和父亲的教育水平。
研究结果支持中文版IH-QOL评估IH患儿及其父母生活质量的可行性和可靠性。血管瘤大小、位置及母亲的教育水平是影响IH患儿及其父母生活质量的重要因素。
