Okocha Chide Emmanuel, Manafa Patrick O, Igwe Chioma Nkechinyere, Okite Uchechukwu Prince, Onah Christian Ejike, Efobi Chilota
Haematology Department, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria.
Front Genet. 2022 Feb 23;13:799425. doi: 10.3389/fgene.2022.799425. eCollection 2022.
Hemoglobin polymerization in sickle cell anemia (SCA) leads to abnormally rigid and adhesive erythrocytes that obstruct blood vessels, leading to poor tissue perfusion, hence provoking inflammation and damage of surrounding tissues. Adiponectin, a protein hormone, presumptively has anti-inflammatory characteristics, hence may be an important therapeutic target in SCA. The aim of the study was to evaluate the status of adiponectin and its correlation with disease severity in SCA. A total of 84 subjects were recruited for the study comprising 34 homozygous sickle cell (HbSS) subjects (25 in the steady state and nine in the resolving crisis state) and 50 controls (25 heterozygous sickle cell [HbAS] and 25 hemoglobin phenotype AA subjects). The hemoglobin phenotype, adiponectin levels, and full blood counts were evaluated. Anthropometric measurements were also conducted. A significant difference was observed in the mean body mass index between the different hemoglobin phenotype groups and also between the SCA in crisis resolution patients and the control group ( < 0.05). There was no significant difference in the median serum levels of adiponectin in the different hemoglobin phenotype groups and between SCA patients in the steady state compared with those in the crisis resolution state. Also, there was no correlation between disease severity and adiponectin in SCA patients in the steady state ( = 0.87). Our study seems to suggest that in our data set of sickle cell anemia patients in the steady state, adiponectin does not constitute part of the endocrinopathy that affects these patients.
镰状细胞贫血（SCA）中的血红蛋白聚合会导致红细胞异常僵硬且具有黏附性，从而阻塞血管，导致组织灌注不良，进而引发周围组织的炎症和损伤。脂联素是一种蛋白质激素，据推测具有抗炎特性，因此可能是SCA的一个重要治疗靶点。本研究的目的是评估脂联素的状态及其与SCA疾病严重程度的相关性。共有84名受试者参与了该研究，其中包括34名纯合子镰状细胞（HbSS）受试者（25名处于稳定状态，9名处于缓解期危机状态）和50名对照者（25名杂合子镰状细胞[HbAS]和25名血红蛋白表型为AA的受试者）。对血红蛋白表型、脂联素水平和全血细胞计数进行了评估。还进行了人体测量。不同血红蛋白表型组之间以及处于危机缓解期的SCA患者与对照组之间的平均体重指数存在显著差异（<0.05）。不同血红蛋白表型组之间以及稳定状态的SCA患者与危机缓解期患者之间的脂联素血清中位数水平无显著差异。此外，稳定状态的SCA患者中疾病严重程度与脂联素之间无相关性（=0.87）。我们的研究似乎表明，在我们的数据集中，处于稳定状态的镰状细胞贫血患者中，脂联素并不构成影响这些患者的内分泌病变的一部分。
