Zhang Xiaobei, Zheng Ying, Liu Xiaofeng, Wang Kaiyuan, Zhao Hongwei, Yin Yiqing, Yu Yue
Department of Anesthesiology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Ann Transl Med. 2022 Jan;10(2):81. doi: 10.21037/atm-21-6611.
Homeobox gene C10 () plays a vital role in the occurrence and development of several cancers, but its effects and underlying mechanism in the prognosis of different subtypes of breast cancer remain unclear.
First, we evaluated and compared the expression levels of cancer to normal tissues in the Oncomine and Tumor Immune Estimation Resource (TIMER) databases. Second, the correlation between and the survival of patients with different types of cancer, including breast cancer, was analyzed in the PrognoScan, Gene Expression Profiling Interactive Analysis (GEPIA), and Kaplan-Meier plotter databases. Finally, the relationship between and immune-infiltration levels or gene marker sets of immune cells in basal-like breast cancer (BLBC) was investigated in the TIMER and GEPIA databases.
The expression of was elevated in breast cancer tissues. High expression indicated a poor prognosis for breast cancer patients, and expression affected the survival time of lymph-node positive or grade III breast cancer patients. In BLBC, the median overall survival (OS) of patients with high expression was significantly shorter than that of patients with low expression. was positively correlated with the immune infiltration of macrophages in BLBC. Breast cancer patients with low expression in different enriched immune-cell subgroups had a favorable prognosis.
The level of expression increased significantly in breast cancer, and elevated was positively correlated with immune-cell infiltration and poor prognosis in BLBC. These findings shed light on the important role of in breast cancer. should be recognized as a prognostic biomarker for determining prognosis and immune infiltration in BLBC patients.
同源盒基因C10（）在多种癌症的发生和发展中起着至关重要的作用，但其在不同亚型乳腺癌预后中的作用及潜在机制仍不清楚。
首先，我们在Oncomine和肿瘤免疫评估资源（TIMER）数据库中评估并比较了癌组织与正常组织中 的表达水平。其次，在PrognoScan、基因表达谱交互式分析（GEPIA）和Kaplan-Meier绘图仪数据库中分析了 与包括乳腺癌在内的不同类型癌症患者生存之间的相关性。最后，在TIMER和GEPIA数据库中研究了 与基底样乳腺癌（BLBC）中免疫细胞浸润水平或免疫细胞基因标志物集之间的关系。
乳腺癌组织中 的表达升高。高 表达表明乳腺癌患者预后不良，且表达影响淋巴结阳性或III级乳腺癌患者的生存时间。在BLBC中，高 表达患者的中位总生存期（OS）明显短于低 表达患者。 与BLBC中巨噬细胞的免疫浸润呈正相关。在不同富集免疫细胞亚组中低 表达的乳腺癌患者预后良好。
乳腺癌中 的表达水平显著升高，且升高的 与BLBC中的免疫细胞浸润和不良预后呈正相关。这些发现揭示了 在乳腺癌中的重要作用。 应被视为确定BLBC患者预后和免疫浸润的预后生物标志物。
