Chaulk C P, Smith P W, Sass H J
J Clin Microbiol. 1986 Aug;24(2):315-6. doi: 10.1128/jcm.24.2.315-316.1986.
A case of visceral leishmaniasis in a young American Peace Corps volunteer is reported. Both clinical and epidemiologic evidence strongly supported the diagnosis; however, hepatic and splenic aspirates for the causative organism were negative. The diagnosis was eventually confirmed through serology, employing indirect immunofluorescence and complement fixation testing of serum. The patient clinically responded dramatically to sodium stibogluconate, the drug of choice for the treatment of visceral leishmaniasis. This case is significant because it alerts the physician to an unusual cause of fever of unknown origin in residents of the Western nations and demonstrates the potential usefulness of serology in diagnosing visceral leishmaniasis when the infecting organism cannot be isolated.
报告了一例年轻的美国和平队志愿者患内脏利什曼病的病例。临床和流行病学证据都有力地支持了这一诊断；然而，用于检测致病生物体的肝穿刺和脾穿刺抽吸物均为阴性。最终通过血清学检查确诊，采用血清间接免疫荧光和补体结合试验。患者对治疗内脏利什曼病的首选药物葡萄糖酸锑钠有显著临床反应。该病例具有重要意义，因为它提醒医生注意西方国家居民不明原因发热的一种不寻常病因，并证明了在无法分离出感染生物体时血清学在诊断内脏利什曼病方面的潜在用途。
