1University of Novi Sad, Faculty of Medicine, Department of Periodontology and Oral Medicine, Novi Sad, Serbia; 2Dentistry Clinic, Novi Sad, Serbia; 3Department of Human Genetics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia.
Acta Clin Croat. 2022 Feb;60(3):406-414. doi: 10.20471/acc.2021.60.03.10.
Chronic periodontitis is a common complication in diabetes. The aim of this study was to evaluate some clinical and microbiological parameters in controlled and uncontrolled type 2 diabetes mellitus (type 2 DM) patients compared to non-diabetic (NDM) individuals, as well as to assess the effect of non-surgical periodontal therapy on these parameters. The study was performed in 61 type 2 DM patients with periodontitis (group 1A: 29 patients having achieved good metabolic control, HbA1c <7%; group 1B: 32 patients with poor metabolic control, HbA1c ≥7%), and 31 NDM individuals suffering from periodontitis. Periodontal indices (plaque index, PI; gingival index, GI; probing pocket depth, PPD; and clinical attachment level, CAL) were measured and subgingival plaque samples were analyzed using polymerase chain reaction prior to treatment initiation and 3 months post-treatment. The results recorded on the majority of measured parameters indicated that differences in treatment success achieved in the three treatment groups were not statistically significant (∆PI p=0.646; ∆GI p=0.303; and ∆CAL p=0.233). Likewise, comparison of the effectiveness in microorganism reduction revealed no significant differences between DM groups and NDM patients. Therefore, study results supported the hypothesis that periodontal therapy outcome was unaffected by the level of glycemic control in patients with diabetes.
慢性牙周炎是糖尿病的常见并发症。本研究旨在评估 2 型糖尿病（2 型 DM）患者（控制组：29 例糖化血红蛋白 <7%；未控制组：32 例糖化血红蛋白≥7%）与非糖尿病（NDM）个体之间的一些临床和微生物学参数，并评估非手术牙周治疗对这些参数的影响。该研究纳入了 61 例患有牙周炎的 2 型 DM 患者（1A 组：29 例代谢控制良好，糖化血红蛋白 <7%；1B 组：32 例代谢控制不佳，糖化血红蛋白≥7%）和 31 例患有牙周炎的 NDM 个体。在治疗开始前和治疗后 3 个月，测量牙周指数（菌斑指数、GI；探诊袋深度、CAL）并使用聚合酶链反应分析龈下菌斑样本。大多数测量参数的结果表明，三组治疗的治疗成功率差异无统计学意义（∆PI p=0.646；∆GI p=0.303；∆CAL p=0.233）。同样，对微生物减少的有效性进行比较，DM 组和 NDM 患者之间也没有发现显著差异。因此，研究结果支持了这样一种假设，即牙周治疗效果不受糖尿病患者血糖控制水平的影响。
