Gaziantep 25 Aralık State Hospital, Psychiatry Clinic, Gaziantep, Turkey.
Department of Psychiatry, Faculty of Medicine, Gazi University, Ankara, Turkey.
Nord J Psychiatry. 2022 Apr;76(3):162-169. doi: 10.1080/08039488.2022.2048887. Epub 2022 Mar 12.
When depressive symptoms in bipolar and unipolar patients were compared, a number of studies reported that atypical vegetative features such as hypersomnia and hyperphagia were more common in bipolar patients. Moreover, neuropeptides such as orexin-A (ORX-A), ghrelin (GRL), and neuropeptide Y (NPY) are involved in the regulation of these vegetative functions.
A total of 45 unipolar and 24 bipolar depressive patients, and 36 euthymic healthy controls were included in the study. The groups were compared in terms of peripheral blood samples of ORX-A, GRL, and NPY levels, as well as HAM-D, Epworth Sleepiness Scale, Three-Factor Eating Questionnaire-Revised, and Suicide Probability Scale scores.
Both unipolar and bipolar patients had lower ORX-A, GRL, and NPY levels compared to the controls, whereas NPY levels of bipolar patients were lower than unipolar patients. There was a negative correlation between NPY levels and emotional eating in the bipolar group.
While lower ORX-A, GRL, and NPY levels are associated with depressive episodes regardless of the diagnosis; NPY levels also differ in bipolar and unipolar depression patients.
当比较双相和单相患者的抑郁症状时，许多研究报告称，双相患者更常出现不典型的植物神经特征，如嗜睡和贪食。此外，神经肽如食欲素-A（ORX-A）、胃饥饿素（GRL）和神经肽 Y（NPY）参与这些植物神经功能的调节。
本研究共纳入 45 例单相和 24 例双相抑郁患者以及 36 例健康对照者。比较了三组外周血 ORX-A、GRL 和 NPY 水平以及 HAM-D、Epworth 嗜睡量表、三因素饮食问卷修订版和自杀可能性量表评分。
与对照组相比，单相和双相患者的 ORX-A、GRL 和 NPY 水平均较低，而双相患者的 NPY 水平低于单相患者。双相组 NPY 水平与情绪性进食呈负相关。
虽然无论诊断如何，较低的 ORX-A、GRL 和 NPY 水平与抑郁发作有关，但 NPY 水平在双相和单相抑郁患者中也存在差异。
