Shah Surbhi, Padrnos Leslie
Division of Hematology and Medical Oncology, Mayo Clinic Arizona, 5881 E. Mayo Boulevard, Phoenix, AZ 85054, USA.
Division of Hematology and Medical Oncology, Mayo Clinic Arizona, 5881 E. Mayo Boulevard, Phoenix, AZ 85054, USA.
Hematol Oncol Clin North Am. 2022 Apr;36(2):353-363. doi: 10.1016/j.hoc.2021.12.003. Epub 2022 Mar 11.
Autoimmune hemolytic anemia (AHIA) is the group of acquired autoimmune conditions resulting from the development of autologous antibodies directed against autologous red blood cell antigens resulting in red cell lysis. Beyond the presence, severity, and duration of hemolysis which can lead to symptomatic anemia, additional complications at presentation and during treatment require a high degree of clinical vigilance. These include among others cutaneous, thrombotic, renal disorders, and infectious disorders. Complications can be due to the presence of the pathologic antibody itself, the process of hemolysis, or attributed to treatment. Comprehensive management of AIHA requires awareness and assessment of complications at diagnosis, during, and following treatment.
自身免疫性溶血性贫血（AHIA）是一组获得性自身免疫性疾病，由针对自身红细胞抗原产生的自身抗体导致红细胞溶解引起。除了溶血的存在、严重程度和持续时间可导致症状性贫血外，就诊时和治疗期间的其他并发症需要高度的临床警惕。其中包括皮肤、血栓形成、肾脏疾病和感染性疾病。并发症可能是由于病理性抗体本身的存在、溶血过程或归因于治疗。自身免疫性溶血性贫血的综合管理需要在诊断、治疗期间和治疗后认识并评估并发症。
