Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA; Section of Clinical Chemistry, Division of Laboratory Medicine, Department of Pathology, Texas Children's Hospital, Houston, TX 77030, USA.
Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Clin Chim Acta. 2022 Jun 1;531:68-70. doi: 10.1016/j.cca.2022.02.017. Epub 2022 Mar 10.
Pegasparagase (PEG-Asparaginase) induced hypertriglyceridemia is rare in the treatment of lymphoblastic lymphoma in children. We present a case of PEG-asparaginase induced hypertriglyceridemia that was incidentally identified and suspicion of its interference with sodium measurement in the clinical laboratory. The use of a direct ion selective method clarified the presence of true hyponatremia. The patient was treated with an oral Fenofibrate therapy which resolved the hypertriglyceridemia. This case highlights that PEG-asparaginanse and Olazanpine can induce hypertriglyceridemia in acute lymphoblastic leukemia and it may be useful to obtain baseline triglyceride measurements for these patients.
培门冬酶（PEG-天冬酰胺酶）引起的高甘油三酯血症在儿童急性淋巴细胞白血病的治疗中较为罕见。我们报告了 1 例培门冬酶引起的高甘油三酯血症，该患者在临床实验室检测中偶然被发现，并怀疑其对钠测量的干扰。直接离子选择法的使用澄清了真正低钠血症的存在。该患者接受了口服非诺贝特治疗，高甘油三酯血症得到了缓解。该病例强调了培门冬酶和奥拉曲坦可能会引起急性淋巴细胞白血病患者的高甘油三酯血症，因此对这些患者进行基线甘油三酯测量可能是有用的。
