颠茄叶中具有抗炎活性的 4 种新的茄参内酯。
Four new withanolides with anti-inflammatory activity from Datura inoxia Mill. leaves.
机构信息
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin 150040, People's Republic of China.
出版信息
Steroids. 2022 Jun;182:109010. doi: 10.1016/j.steroids.2022.109010. Epub 2022 Mar 11.
Four previously undescribed withanolides, datinolides A-D (1-4) and eight known withanolides (5-12), were separated from the 70% ethyl alcohol extract of Datura inoxia Mill. leaves. All structures were clarified by comprehensive spectroscopic analysis. Furthermore, all withanolides were assessed for their anti-inflammatory activity and results showed that 1 exhibited a fairly good suppression against nitric oxide generation in lipopolysaccharide-stimulated RAW 264.7 cells (IC = 10.33 ± 1.53 μM).
从曼陀罗（Datura inoxia Mill.）叶的 70%乙醇提取物中分离得到了 4 种以前未描述过的醉茄内酯，即 datinolide A-D（1-4）和 8 种已知的醉茄内酯（5-12）。通过综合光谱分析确定了所有结构。此外，还评估了所有醉茄内酯的抗炎活性，结果表明，化合物 1 对脂多糖刺激的 RAW 264.7 细胞中一氧化氮的生成具有相当好的抑制作用（IC=10.33±1.53μM）。
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