Giebink G S, Warkentin P I, Ramsay N K, Kersey J H
J Infect Dis. 1986 Oct;154(4):590-6. doi: 10.1093/infdis/154.4.590.
To understand the susceptibility of allogeneic bone marrow transplant recipients to pneumococcal infection, we measured the level of type-specific antibodies to pneumococcal capsular polysaccharide in serum from ten marrow recipients. Seven recipients received marrow from matched sibling donors who had recently been vaccinated with polyvalent pneumococcal vaccine. Titers of IgG antibodies to two pneumococcal serotypes (7F and 14) declined significantly during the first year after transplantation. IgM antibodies remained low or declined after transplantation, but IgM antibodies to type 7F increased during the latter half of the first year. Pneumococcal vaccine was administered to seven marrow recipients approximately two years after transplantation. Vaccinated recipients had lower postvaccination titers of type-specific IgG antibody than did vaccinated normal adults and vaccinated sibling donors, and the recipients had normal levels of type-specific IgM antibodies. Thus, the susceptibility of marrow graft recipients to pneumococcal disease may be related to lowered concentrations of antibody to pneumococci after engraftment.
为了解异基因骨髓移植受者对肺炎球菌感染的易感性，我们检测了10名骨髓移植受者血清中针对肺炎球菌荚膜多糖的型特异性抗体水平。7名受者接受了来自近期接种过多价肺炎球菌疫苗的匹配同胞供者的骨髓。移植后第一年，针对两种肺炎球菌血清型（7F和14）的IgG抗体滴度显著下降。移植后IgM抗体水平保持较低或下降，但针对7F型的IgM抗体在第一年下半年有所增加。大约在移植后两年，对7名骨髓移植受者接种了肺炎球菌疫苗。与接种疫苗的正常成年人及接种疫苗的同胞供者相比，接种疫苗的受者接种后型特异性IgG抗体滴度较低，且受者的型特异性IgM抗体水平正常。因此，骨髓移植受者对肺炎球菌疾病的易感性可能与移植后针对肺炎球菌的抗体浓度降低有关。
